| Literature DB >> 603317 |
U Scapagnini, L Annunziato, G F Di Renzo, G Schettini, P Preziosi.
Abstract
Clonidine, injected i.p. 20 min before cold exposure, is able to counteract the blockade induced by alpha-methyl-p-tyrosine of cold-stimulated release of TSH in rats. Under basal conditions the alpha-adrenoceptor stimulating agent, administered into the lateral cerebral ventricle (10 microgram), produces, at 30 min, a sharp increase in plasma TSH that returns to control levels at 60 min. When the drug is given intraperitoneally (0.4 mg/kg) it causes a significant decrease in plasma TSH 120 min after the treatment.Entities:
Mesh：
Substances：
Year: 1977 PMID： 603317
Source DB: PubMed Journal: Arch Int Pharmacodyn Ther ISSN： 0003-9780