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Literature DB >> 6032987

Physiology of rat-liver polysomes. The stability of messenger ribonucleic acid and ribosomes.

Abstract

Starvation of rats for several days led to marked decrease in cytoplasmic polysomes and accumulation of breakdown products having S values less than 200s. Re-feeding of the starved animals induced a rapid reassembly of polysomes. These newly formed polysomes, in the presence of actinomycin D, decayed in a biphasic fashion: about two-thirds decayed with an apparent half-life of 3-3(1/2)hr. but the other one-third were much more stable. Evidence that polysome decay is an accurate reflexion of messenger RNA stability is presented, and it is concluded that in the presence of large doses of actinomycin D, rat-liver cytoplasm contains messenger RNA classes of widely varying stability, the more stable class having a half-life of at least 80hr. The half-life of liver ribosomes was also determined and was found to be 110-127hr.

Entities: Chemical Species

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Year: 1967 PMID： 6032987 PMCID： PMC1270442 DOI： 10.1042/bj1030556

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

42 in total

1. Template stability of some enzymes in rat liver and hepatoma.

Authors: H C Pitot; C Peraino; C Lamar; A L Kennan
Journal: Proc Natl Acad Sci U S A Date: 1965-09 Impact factor: 11.205

2. Sedimentation characteristics of template RNA from rabbit reticulocytes and rat liver.

Authors: G Brawerman; N Biezunski; J Eisenstadt
Journal: Biochim Biophys Acta Date: 1965-06-08

3. Ribonucleic acid composition of bacteria as a function of growth rate.

Authors: R Rosset; J Julien; R Monier
Journal: J Mol Biol Date: 1966-07 Impact factor: 5.469

4. Turnover of ribosomal RNA in rat liver.

Authors: J N Loeb; R R Howell; G M Tomkins
Journal: Science Date: 1965-09-03 Impact factor: 47.728

5. Studies on the nature of polysomes.

Authors: A J Munro; R J Jackson; A Korner
Journal: Biochem J Date: 1964-08 Impact factor: 3.857

6. Studies on the physiology of rat liver polyribosomes: quantition and intracellular distribution of ribosomes.

Authors: S H Wilson; M B Hoagland
Journal: Proc Natl Acad Sci U S A Date: 1965-08 Impact factor: 11.205

7. A cytoplasmic particle bearing messenger ribonucleic acid in rat liver.

Authors: E C Henshaw; M Revel; H H Hiatt
Journal: J Mol Biol Date: 1965-11 Impact factor: 5.469

8. A helical polysome model.

Authors: P Pfuderer; P Cammarano; D R Holladay; G D Novelli
Journal: Biochim Biophys Acta Date: 1965-11-29

9. Liver sRNA synthesis in actinomycin D-treated rats.

Authors: Y Moulé; R M Landin
Journal: Biochem Biophys Res Commun Date: 1965-08-16 Impact factor: 3.575

10. Ion-exchange thin-layer chromatography. XV. Preparation, properties and applications of paper-like PEI-cellulose sheets.

Authors: K Randerath; E Randerath
Journal: J Chromatogr Date: 1966-04

29 in total

1. The regulation of protein synthesis in the liver of rats. Mechanisms of dietary amino acid control in the immature animal.

Authors: R W Wannemacher; W K Cooper; M B Yatvin
Journal: Biochem J Date: 1968-05 Impact factor: 3.857

2. The distribution of ribosomes between different functional states in livers of fed and starved mice.

Authors: M Norman; S Gamulin; K Clark
Journal: Biochem J Date: 1973-06 Impact factor: 3.857

Review 3. The synthesis and degradation of liver-produced proteins.

Authors: A S Tavill
Journal: Gut Date: 1972-03 Impact factor: 23.059

4. Polysome profile and free alkaline ribonuclease activity of placenta and maternal liver of intact, starved and X-irradiated mice.

Authors: U Tarachand; J Eapen
Journal: Experientia Date: 1974-03-15

5. Persistent circadian rhythmicity of protein synthesis in the liver of starved rats.

Authors: A V LeBouton; S D Handler
Journal: Experientia Date: 1971-09-15

6. Characterization of the rapidly labeled hybridizable RNA synthesized in L5178Y mouse leukemic cells. Hybridization lifetime studies.

Authors: M Meltz; S Okada
Journal: Biophys J Date: 1971-07 Impact factor: 4.033

Review 7. Serum albumin.

Authors: M A Rothschild; M Oratz; S S Schreiber
Journal: Am J Dig Dis Date: 1969-10

8. Ribosomes and Polysomes in Cucumber Leaves during Growth and Senescence.

Authors: Y Eilam; R D Butler; E W Simon
Journal: Plant Physiol Date: 1971-02 Impact factor: 8.340

9. Protein initiation in eukaryotes: formation and function of a ternary complex composed of a partially purified ribosomal factor, methionyl transfer RNA, and guanosine triphosphate.

Authors: D H Levin; D Kyner; G Acs
Journal: Proc Natl Acad Sci U S A Date: 1973-01 Impact factor: 11.205

10. Effect of tryptophan on rat hepatic nuclear poly(A)polymerase activity.

Authors: R N Kurl; E Verney; H Sidransky
Journal: Amino Acids Date: 1993-06 Impact factor: 3.520