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Literature DB >> 6029617

Formation of retinoic acid from retinol in the rat.

Abstract

1. The formation in vivo of retinoic acid from microgram quantities of intrajugularly administered [15-(14)C]retinol was demonstrated in the rat. 2. Endogenously formed retinoic acid (about 0.1mug./rat) was found in liver, and to a much smaller extent in intestine, 12hr. after retinol administration. 3. Excretion of some of the endogenously formed retinoic acid occurred in the bile of bile-duct-cannulated rats. 4. Excretion of unaltered retinoic acid in the urine of intact rats did not occur even after the intrajugular administration of preformed retinoic acid.

Entities: Chemical Species

Mesh：

Substances：
Vitamin A

Year: 1967 PMID： 6029617 PMCID： PMC1270286 DOI： 10.1042/bj1020606

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

15 in total

1. BIOSYNTHESIS OF L-SERINE ETHANOLAMINE PHOSPHODIESTER.

Authors: H ROSENBERG; A H ENNOR; S SUGAI
Journal: Nature Date: 1964-07-25 Impact factor: 49.962

2. IDENTIFICATION OF FREE AND CONJUGATED RETINOIC ACID AS A PRODUCT OF RETINAL (VITAMIN A ALDEHYDE) METABOLISM IN THE RAT IN VIVO.

Authors: P E DUNAGIN; R D ZACHMAN; J A OLSON
Journal: Biochim Biophys Acta Date: 1964-08-19

3. ACTION OF VITAMIN A ON LIVER HOMOGENATE OXIDATION OF TRICARBOXYLIC ACID CYCLE INTERMEDIATES.

Authors: H F Deluca; M R Manatt; N Madsen; E B Olson
Journal: J Nutr Date: 1963-12 Impact factor: 4.798

4. SIMPLE, MULTIBORE COLUMNS FOR SUPERIOR FRACTIONATION OF LIPIDS.

Authors: G A FISCHER; J J KABARA
Journal: Anal Biochem Date: 1964-11 Impact factor: 3.365

5. VITAMIN A AND REPRODUCTION IN RATS.

Authors: J N THOMPSON; J M HOWELL; G A PITT
Journal: Proc R Soc Lond B Biol Sci Date: 1964-02-18

6. Bioassay of vitamin A compounds.

Authors: P L HARRIS
Journal: Vitam Horm Date: 1960 Impact factor: 3.421

7. Determination of vitamin A acid in human plasma after oral administration.

Authors: L JURKOWITZ
Journal: Arch Biochem Biophys Date: 1962-08 Impact factor: 4.013

8. THE BIOLOGICAL FUNCTION OF VITAMIN A ACID.

Authors: J E Dowling; G Wald
Journal: Proc Natl Acad Sci U S A Date: 1960-05 Impact factor: 11.205

9. Pathways of retinol and retinoic acid metabolism in the rat.

Authors: A B Roberts; H F DeLuca
Journal: Biochem J Date: 1967-02 Impact factor: 3.857

10. Rapid conversion of retinal (vitamin A aldehyde) to retinoic acid (vitamin A acid) in the living rat.

Authors: D S Deshmukh; P Malathi; J Ganguly
Journal: Biochim Biophys Acta Date: 1965-08-24

13 in total

1. Identification of 5,8-oxyretinoic acid isolated from small intestine of vitamin A-deficient rats dosed with retinoic acid.

Authors: J L Napoli; A M McCormick; H K Schnoes; H F DeLuca
Journal: Proc Natl Acad Sci U S A Date: 1978-06 Impact factor: 11.205

2. [Contaminating substances in 22 over-the-counter fish oil and cod liver oil preparations: cholesterol, heavy metals and vitamin A].

Authors: H Koller; C Luley; B Klein; H Baum; H K Biesalski
Journal: Z Ernahrungswiss Date: 1989-03

Formation of retinoic acid from retinol in the rat.

1. BIOSYNTHESIS OF L-SERINE ETHANOLAMINE PHOSPHODIESTER.

2. IDENTIFICATION OF FREE AND CONJUGATED RETINOIC ACID AS A PRODUCT OF RETINAL (VITAMIN A ALDEHYDE) METABOLISM IN THE RAT IN VIVO.

3. ACTION OF VITAMIN A ON LIVER HOMOGENATE OXIDATION OF TRICARBOXYLIC ACID CYCLE INTERMEDIATES.

4. SIMPLE, MULTIBORE COLUMNS FOR SUPERIOR FRACTIONATION OF LIPIDS.

5. VITAMIN A AND REPRODUCTION IN RATS.

6. Bioassay of vitamin A compounds.

7. Determination of vitamin A acid in human plasma after oral administration.

8. THE BIOLOGICAL FUNCTION OF VITAMIN A ACID.

9. Pathways of retinol and retinoic acid metabolism in the rat.

10. Rapid conversion of retinal (vitamin A aldehyde) to retinoic acid (vitamin A acid) in the living rat.

1. Identification of 5,8-oxyretinoic acid isolated from small intestine of vitamin A-deficient rats dosed with retinoic acid.

2. [Contaminating substances in 22 over-the-counter fish oil and cod liver oil preparations: cholesterol, heavy metals and vitamin A].

3. Studies on the in vivo metabolism of retinoic acid in the rat.

4. Retinoic acid: topical treatment of senile or actinic keratoses and basal cell carcinomas.

5. Binding of all-trans-retinoic acid to MLTC-1 proteins.

6. Prophylaxis of chemically induced papillomas and carcinomas of mouse skin by vitamin A-acid.

Review 7. Retinoic Acid Synthesis and Degradation.

8. All-trans-retinol is a ligand for the retinoic acid receptors.

9. Metabolic studies on retinoic acid in the rat.

10. Characterization of retinoyl beta-glucuronide as a minor metabolite of retinoic acid in bile.