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Literature DB >> 6028919

Polydipsia elicited by the synergistic action of a saccharin and glucose solution.

E S Valenstein, V C Cox, J W Kakolewski.

Abstract

Rats consume significantly more of a solution combining saccharin and glucose than equivalent solutions of these substances presented in separate bottles. Fluid consumption may exceed body weight. Experiments helping to delineate the basis of this synergistic action are presented.

Entities: Chemical Disease Species

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Year: 1967 PMID： 6028919 DOI： 10.1126/science.157.3788.552

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

28 in total

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Polydipsia elicited by the synergistic action of a saccharin and glucose solution.

Review 1. Preclinical studies of alcohol binge drinking.

2. A modified adjusting delay task to assess impulsive choice between isocaloric reinforcers in non-deprived male rats: effects of 5-HT₂A/C and 5-HT₁A receptor agonists.

3. Effects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats.

4. Intravenous cocaine self-administration in rats is reduced by dietary L-tryptophan.

5. A concurrently available nondrug reinforcer prevents the acquisition or decreases the maintenance of cocaine-reinforced behavior.

6. The effect of insulin-induced hypoglycemia on NaCl hunger in the adrenalectomized rat.

7. Propensity for social interaction predicts nicotine-reinforced behaviors in outbred rats.

8. The role of matrix metalloproteinase-9 in negative reinforcement learning and plasticity in alcohol dependence.

9. Autoshaping i.v. cocaine self-administration in rats: effects of nondrug alternative reinforcers on acquisition.

10. Modeling hypohedonia following repeated social defeat: Individual vulnerability and dopaminergic involvement.