Literature DB >> 602875

The effect of hexamethonium on gastric acid secretion in the conscious rat.

K T Bunce, M E Parsons.   

Abstract

Evidence against a role for histamine in pentagastrin-stimulated acid secretion has been obtained previously using hexamethonium in gastric fistula rats. This possibility has been re-examined in conscious rats provided with gastric fistulae or Heidenhain pouches. Hexamethonium (20 mg/kg s.c.) inhibited basal acid secretion and acid secretion stimulated by histamine and pentagastrin in gastric fistula rats. The same dose of hexamethonium failed to produce a significant inhibition of acid secretion stimulated by bethanechol, pentagastrin or histamine in the presence of a low dose of bethanechol in Heidenhain pouch rats. These results provide no evidence to oppose the view that pentagastrin-stimulated acid secretion in the rat is mediated at least in part through the mobilization of gastric mucosal histamine. The inhibition of secretagogue induced acid secretion in the gastric fistula rat is mainly the result of a reduction in the basal acid output.

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Year:  1977        PMID： 602875     DOI： 10.1007/bf02111122

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  15 in total

1.  Preparation of chronic denervated gastric pouches in the rat.

Authors:  R S ALPHIN; T M LIN
Journal:  Am J Physiol       Date:  1959-08

2.  Response of the chronic gastric fistula rat to histamine.

Authors:  A LANE; A C IVY; E K IVY
Journal:  Am J Physiol       Date:  1957-08

3.  The effect of the ganglion-blocking methonium salts on gastric secretion and motility.

Authors:  A W KAY; A N SMITH
Journal:  Gastroenterology       Date:  1951-08       Impact factor: 22.682

4.  The role of the intramural cholinergic innervation in the acid response of the parietal cell to gastrin derivatives.

Authors:  J S Davison; P C Fahrner; B Schofield; B L Tepperman
Journal:  Can J Physiol Pharmacol       Date:  1974-06       Impact factor: 2.273

5.  The action of some agents active at autonomic ganglionic sites on the secretory response of the Heidenhain pouch to various stimuli.

Authors:  Y Odori; D F Magee
Journal:  Eur J Pharmacol       Date:  1969-11       Impact factor: 4.432

6.  The effect of hexamethonium on gastric acid and pepsin response to pentagastrin, histamine and AHR-602.

Authors:  S Nakajima; D F Magee
Journal:  Eur J Pharmacol       Date:  1970-05       Impact factor: 4.432

7.  The effect of vagal block or hexamethonium on gastric secretion in the dog.

Authors:  J M Limbosch; J H Wyllie; L M Nyhus
Journal:  Scand J Gastroenterol       Date:  1968       Impact factor: 2.423

8.  Mechanism of activation of rat stomach histidine decarboxylase after vagal denervation.

Authors:  R Håkanson; G Liedberg
Journal:  Eur J Pharmacol       Date:  1971-09       Impact factor: 4.432

9.  The role of endogenous gastrin in the activation of gastric histidine decarboxylase in the rat. Effect of antrectomy and vagal denervation.

Authors:  R Håkanson; G Liedberg
Journal:  Eur J Pharmacol       Date:  1970-09-01       Impact factor: 4.432

10.  The pharmacological action of gastrin pentapeptide.

Authors:  Y Odori; D F Magee
Journal:  Experientia       Date:  1969-02-15
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  7 in total

1.  Inhibition of pepsin secretion by metiamide and atropine in the conscious rat.

Authors:  K T Bunce; M E Parsons; F R Matheson
Journal:  Agents Actions       Date:  1979-06

2.  The effect of CCKB/gastrin antagonists on stimulated gastric acid secretion in the anaesthetized rat.

Authors:  N J Hayward; M Harding; S A Lloyd; A T McKnight; J Hughes; G N Woodruff
Journal:  Br J Pharmacol       Date:  1991-12       Impact factor: 8.739

3.  Cholinergic components in the gastrin pathway of gastric acid stimulation.

Authors:  I Szelenyi
Journal:  Experientia       Date:  1980-08-15

4.  Cholinergic control of gastric acid secretion.

Authors:  F Pagani; A Brambilla; A Schiavone; A Giachetti
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-03       Impact factor: 3.000

5.  Inhibition by metiamide of secretagogue-induced gastric acid secretion in the conscious Heidenhain pouch rat.

Authors:  K T Bunce; M E Parsons
Journal:  J Physiol       Date:  1978-12       Impact factor: 5.182

6.  Lack of cholinergic innervation in gastric mucosa does not affect gastrin secretion or basal acid output in neurturin receptor GFRα2 deficient mice.

Authors:  Jussi Kupari; Jari Rossi; Karl-Heinz Herzig; Matti S Airaksinen
Journal:  J Physiol       Date:  2013-01-21       Impact factor: 5.182

7.  The effect cystamine on gastric secretion in the rat.

Authors:  M E Parsons; K T Bunce; A Currington; F Matheson; G Pipkin
Journal:  Agents Actions       Date:  1979-08
  7 in total

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