Literature DB >> 6025543

Pyrimidine nucleotide synthesis: regulatory control during transformation of lymphocytes in vitro.

Z J Lucas.   

Abstract

The incorporation of uridine into RNA in lymphocytes undergoing transformation induced by phytohemagglutinin parallels its incorporation into the intratcellular pool of acid-soluble nucleotides and coincides with a 20-fold increase in the specific activity of uridine kinase. This increase is dependent upon synthesis of both RNA and protein and is subject to both repression and end-product inhibition by cytidine.

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Year:  1967        PMID： 6025543     DOI： 10.1126/science.156.3779.1237

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  14 in total

1.  Lymphopenic immunologic deficiency in identical twins: lymphocyte allografting and graft-versus-host disease following treatment with albumin-gradient-separated paternal bone marrow cells.

Authors:  R H Buckley; W B Kremer; D T Rowlands; C C Huntley; D B Amos; A T Huang
Journal:  Clin Exp Immunol       Date:  1971-09       Impact factor: 4.330

2.  Inhibition of DNA synthesis by methylglyoxal bis(guanylhydrazone) during lymphocyte transformation.

Authors:  S Otani; Y Mizoguchi; I Matsui; S Morisawa
Journal:  Mol Biol Rep       Date:  1974-12       Impact factor: 2.316

3.  Defective cellular immunity associated with chronic mucocutaneous moniliasis and recurrent staphylococcal botryomycosis: immunological reconstitution by allogeneic bone marrow.

Authors:  R H Buckley; Z J Lucas; B G Hattler; C M Zmijewski; D B Amos
Journal:  Clin Exp Immunol       Date:  1968-02       Impact factor: 4.330

Review 4.  [Lymphocyte stimulation by pokeweed mitogen (PWM)].

Authors:  G Brittinger; E König
Journal:  Klin Wochenschr       Date:  1969-12-15

Review 5.  Cellular and molecular aspects of immune system aging.

Authors:  D L Doggett; M P Chang; T Makinodan; B L Strehler
Journal:  Mol Cell Biochem       Date:  1981-07       Impact factor: 3.396

6.  Studies on the incorporation of [5-3H] uridine during activation and transformation of lymphocytes induced by phytohaemagglutinin. Dependence on the incorporation rate on uridine concentration at certain critical concentrations.

Authors:  D R Forsdyke
Journal:  Biochem J       Date:  1968-03       Impact factor: 3.857

Review 7.  [On the problem of praetherapeutic sensitivity testing of human tumours based on incorporation studies of nucleic acid precursors in vitro (author's transl)].

Authors:  S Seeber; C G Schmidt
Journal:  Klin Wochenschr       Date:  1977-12-01

8.  Incorporation of [5-3H]uridine and attachment of cells to glass during activation of lymphocytes induced by phytohaemagglutinin.

Authors:  D R Forsdyke
Journal:  Biochem J       Date:  1968-06       Impact factor: 3.857

9.  The rapid induction by phytohemagglutinin of increased alpha-aminoisobutyric acid uptake by lymphocytes.

Authors:  J Mendelsohn; A Skinner; S Kornfeld
Journal:  J Clin Invest       Date:  1971-04       Impact factor: 14.808

10.  Combined effects of phytohemagglutinin and staphylococcal enterotoxin B on deoxyribonucleic acid synthesis during blast transformation in human lymphocytes.

Authors:  G E Shambaugh; G R Blumenschein
Journal:  Infect Immun       Date:  1974-02       Impact factor: 3.441
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