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Literature DB >> 6024118

Quantitative studies of phytohemagglutinin-induced DNA and RNA synthesis in normal and agammaglobulinemic leukocytes.

Abstract

Leukocytes from nine patients with acquired agammaglobulinemia were studied in vitro. Synthesis of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) induced by phytohemagglutinin was measured by determination of the degree of incorporation of labeled precursor. Synthesis of both DNA and RNA was decreased in the agammaglobulinemic cells. The presence of an inhibitor in the patients' sera could not be demonstrated. These results suggest that the basic defect in agammaglobulinemia is cellular rather than humoral.

Entities: Disease Species

Mesh：

Substances：
Lectins
RNA
DNA

Year: 1967 PMID： 6024118 PMCID： PMC2138207 DOI： 10.1084/jem.125.5.863

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

33 in total

1. RNA SYNTHESIS IN CULTURES OF NORMAL HUMAN PERIPHERAL BLOOD.

Authors: L B EPSTEIN; F STOHLMAN
Journal: Blood Date: 1964-07 Impact factor: 22.113

2. THE DEVELOPMENT OF LARGE IMMATURE MONONUCLEAR CELLS IN MIXED LEUKOCYTE CULTURES.

Authors: B BAIN; M R VAS; L LOWENSTEIN
Journal: Blood Date: 1964-01 Impact factor: 22.113

3. THE ACTION OF STREPTOLYSIN S ON PERIPHERAL LYMPHOCYTES OF NORMAL SUBJECTS AND PATIENTS WITH ACUTE RHEUMATIC FEVER.

Authors: K HIRSCHHORN; R R SCHREIBMAN; S VERBO; R H GRUSKIN
Journal: Proc Natl Acad Sci U S A Date: 1964-11 Impact factor: 11.205

4. ACQUIRED AGAMMAGLOBULINAEMIA IN SIBLINGS.

Authors: P CHARACHE; F S ROSEN; C A JANEWAY; J M CRAIG; H A ROSENBERG
Journal: Lancet Date: 1965-01-30 Impact factor: 79.321

5. The occurrence of rheumatoid factor and other abnormalities in families of patients with agammaglobulinemia.

Authors: H FUDENBERG; J L GERMAN; H G KUNKEL
Journal: Arthritis Rheum Date: 1962-12

6. [Hereditary lymphoplasmocytic dysgenesis ("alymphocytosis with agammaglobulinemia")].

Authors: W H HITZIG; H WILLI
Journal: Schweiz Med Wochenschr Date: 1961-12-30

7. An assay for the mitogenic activity of phytohemagglutinin preparations.

Authors: D C Tormey; G C Mueller
Journal: Blood Date: 1965-11 Impact factor: 22.113

8. Side-effects of antiarthritic drugs.

Authors: J P Crawford
Journal: Lancet Date: 1965-10-09 Impact factor: 79.321

9. Induction of ribonucleic acid synthesis in human leucocytes by phytohemagglutinin.

Authors: G C Mueller; M L Mahieu
Journal: Biochim Biophys Acta Date: 1966-01-18

10. A metabolic defect of the lymphocytes in a case of hypogammaglobulinaemia.

Authors: I J Forbes; S C Milazzo
Journal: Australas Ann Med Date: 1965-11

8 in total

Review 1. [Lymphocyte culture and its relation to clinical problems].

Authors: E Ambs
Journal: Klin Wochenschr Date: 1969-08-01

2. Immunoglobulin synthesis and lymphocyte transformation by anti-immunoglobulin sera in bursectomized chickens.

Authors: J Iványi; H Marvanova; E Skamene
Journal: Immunology Date: 1969-09 Impact factor: 7.397

3. Influence of chemotherapy and serum factors on the mitogenic response of peripheral leucocytes of leprosy patients to phytohaemagglutinin.

Authors: V L Mehra; G P Talwar; K Balakrishnan; L K Bhutani
Journal: Clin Exp Immunol Date: 1972-10 Impact factor: 4.330

8. Comparison of uridine uptake at 24 hours with thymidine uptake at 72 hours in phytohaemagglutinin-stimulated cultures of pregnant and other subjects.

Authors: T E Blecher; M J Thompson
Journal: J Clin Pathol Date: 1976-08 Impact factor: 3.411