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Literature DB >> 6018507

Lysine transport in human kidney: evidence for two systems.

Abstract

Experiments with slices of human kidney cortex from two control subjects demonstrated two distinct transport systems for lysine (alpha and beta) which differ greatly in affinity and capacity. Both systems were found in kidney from two patients with cystinuria. Studies with rat kidney confirmed these findings. These experiments defined only a single transport system for cystine in kidney from both control and cystinuric subjects.

Entities: Chemical Disease Species

Mesh：

Substances：
Cystine
Lysine

Year: 1967 PMID： 6018507 DOI： 10.1126/science.155.3768.1426

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

12 in total

1. Molecular specificity of the L-arginine reabsorption mechanism. Microperfusion studies in the proximal tubule of rat kidney.

Authors: S Silbernagl; P Deetjen
Journal: Pflugers Arch Date: 1973-06-04 Impact factor: 3.657

2. Influence of additional methyl groups in the N-epsilon-amino position of lysine on the renal handling.

Authors: R Löwer; H Lange; C Eichhorn; K Hempel
Journal: Pflugers Arch Date: 1974-01-11 Impact factor: 3.657

3. The tubular reabsorption of L-cystine and L-cysteine. A common transport system with L-arginine or not?

Authors: S Silbernagl; P Deetjen
Journal: Pflugers Arch Date: 1972 Impact factor: 3.657

4. Renal tubular transport of proline, hydroxyproline, and glycine. 3. Genetic basis for more than one mode of transport in human kidney.

Authors: C R Scriver
Journal: J Clin Invest Date: 1968-04 Impact factor: 14.808

9. Transport of dibasic amino acids, cystine, and tryptophan by cultured human fibroblasts: absence of a defect in cystinuria and Hartnup disease.

Authors: U Groth; L E Rosenberg
Journal: J Clin Invest Date: 1972-08 Impact factor: 14.808

10. Transport of L-lysine by rat renal brush border membrane vesicles.

Authors: B Stieger; G Stange; J Biber; H Murer
Journal: Pflugers Arch Date: 1983-04 Impact factor: 3.657

Lysine transport in human kidney: evidence for two systems.

1. Molecular specificity of the L-arginine reabsorption mechanism. Microperfusion studies in the proximal tubule of rat kidney.

2. Influence of additional methyl groups in the N-epsilon-amino position of lysine on the renal handling.

3. The tubular reabsorption of L-cystine and L-cysteine. A common transport system with L-arginine or not?

4. Renal tubular transport of proline, hydroxyproline, and glycine. 3. Genetic basis for more than one mode of transport in human kidney.

5. Characteristics of cystine and cysteine transport in rat kidney cortex slices.

6. 5-Hydroxy-L-lysine excretion in cystinuria.

7. Dibasic amino acid transport: lessons from human disease.

8. Renal transport of lysine and arginine in lysinuric protein intolerance.

9. Transport of dibasic amino acids, cystine, and tryptophan by cultured human fibroblasts: absence of a defect in cystinuria and Hartnup disease.

10. Transport of L-lysine by rat renal brush border membrane vesicles.