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Literature DB >> 6015570

Effects of tetrodotoxin on excitability of squid giant axons in sodium-free media.

A Watanabe, I Tasaki, I Singer, L Lerman.

Abstract

The effect of tetrodotoxin on excitability of internally perfused squid giant axons immersed in various sodium-free media was examined. Action potentials were found to be suppressed by this substance, with or without sodium ion in the external medium. Tetrodotoxin showed a strong suppressive effect upon action potentials produced in media containing salts of only divalent cations (CaCl(2), CaBr(2), SrCl(2), or BaCl(2)). Our findings concerning the action of tetrodotoxin do not support the separate-channel hypothesis for excitable membranes.

Entities: Chemical Gene

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Year: 1967 PMID： 6015570 DOI： 10.1126/science.155.3758.95

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

22 in total

1. Ca²⁺ entry through Na_V channels generates submillisecond axonal Ca²⁺ signaling.

Authors: Naomi Ak Hanemaaijer; Marko A Popovic; Xante Wilders; Sara Grasman; Oriol Pavón Arocas; Maarten Hp Kole
Journal: Elife Date: 2020-06-17 Impact factor: 8.140

2. Distinguishing splanchnic nerve and chromaffin cell stimulation in mouse adrenal slices with fast-scan cyclic voltammetry.

Authors: Paul L Walsh; Jelena Petrovic; R Mark Wightman
Journal: Am J Physiol Cell Physiol Date: 2010-11-03 Impact factor: 4.249

3. Mode of action of amiloride in toad urinary bladder. An electrophysiological study of the drug action on sodium permeability of the mucosal border.

Authors: K Sudou; T Hoshi
Journal: J Membr Biol Date: 1977-04-07 Impact factor: 1.843

Effects of tetrodotoxin on excitability of squid giant axons in sodium-free media.

1. Ca²⁺ entry through Na_V channels generates submillisecond axonal Ca²⁺ signaling.

2. Distinguishing splanchnic nerve and chromaffin cell stimulation in mouse adrenal slices with fast-scan cyclic voltammetry.

3. Mode of action of amiloride in toad urinary bladder. An electrophysiological study of the drug action on sodium permeability of the mucosal border.

4. Possible mechanism of adrenergic and nonadrenergic inhibition in intestinal smooth muscle cells.

5. On soliton propagation in biomembranes and nerves.

6. Two components of the calcium current in the egg cell membrane of the tunicate.

7. Calcium and potassium currents of the membrane of a barnacle muscle fibre in relation to the calcium spike.

8. Tetrodotoxin-sensitive calcium-conducting channels in the rat hippocampal CA1 region.

9. Neuromuscular transmission without sodium activation of the presynaptic nerve terminal in the lobster.

10. Sodium and calcium components of action potentials in the Aplysia giant neurone.