Literature DB >> 6015530

Tryptophan hydroxylation: measurement in pineal gland, brainstem, and carcinoid tumor.

W Lovenberg, E Jequier, A Sjoerdsma.   

Abstract

Development of a rapid and sensitive radioassay has permitted study of the conversion of tryptophan to 5-hydroxytryptophan in mammalian tissues. Of normal tissues examined, beef and rat pineal gland contained the highest activity. This is the first direct demonstration of tryptophan hydroxylase in this hydroxyindole-rich tissue. Rat and rabbit brainstem and human carcinoid tumor also had quantities of enzyme that could be measured easily. The reaction requires a reduced pteridine and oxygen and is inhibired by Para-Chorophenylalanine.

Entities:  

Mesh：

Substances：

Year:  1967        PMID： 6015530     DOI： 10.1126/science.155.3759.217

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  72 in total

1.  Genetic mapping of the human tryptophan hydroxylase gene on chromosome 11, using an intronic conformational polymorphism.

Authors:  D A Nielsen; M Dean; D Goldman
Journal:  Am J Hum Genet       Date:  1992-12       Impact factor: 11.025

2.  A pharmacological and autoragiographic study on the ultrastructural localization of indoleamine synthesis in the rabbit pineal gland.

Authors:  H J Romijn; M T Mud; P S Wolters
Journal:  Cell Tissue Res       Date:  1977-12-13       Impact factor: 5.249

Review 3.  Melatonin membrane receptors in peripheral tissues: distribution and functions.

Authors:  Radomir M Slominski; Russel J Reiter; Natalia Schlabritz-Loutsevitch; Rennolds S Ostrom; Andrzej T Slominski
Journal:  Mol Cell Endocrinol       Date:  2012-01-08       Impact factor: 4.102

4.  Associations of tryptophan hydroxylase gene polymorphisms with irritable bowel syndrome.

Authors:  S Jun; R Kohen; K C Cain; M E Jarrett; M M Heitkemper
Journal:  Neurogastroenterol Motil       Date:  2010-11-12       Impact factor: 3.598

5.  Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma.

Authors:  T Nomura; M Ohtsuki; S Matsui; C Sumi-Ichinose; H Nomura; Y Hagino; K Iwase; H Ichinose; K Fujita; T Nagatsu
Journal:  J Neural Transm Gen Sect       Date:  1995

6.  Terahertz spectroscopy of brain tissue from a mouse model of Alzheimer's disease.

Authors:  Lingyan Shi; Pavel Shumyatsky; Adrián Rodríguez-Contreras; Robert Alfano
Journal:  J Biomed Opt       Date:  2016-01       Impact factor: 3.170

Review 7.  A review of the multiple actions of melatonin on the immune system.

Authors:  Antonio Carrillo-Vico; Juan M Guerrero; Patricia J Lardone; Russel J Reiter
Journal:  Endocrine       Date:  2005-07       Impact factor: 3.633

8.  Serotonin transporter and receptor expression in osteocytic MLO-Y4 cells.

Authors:  M Bliziotes; A Eshleman; B Burt-Pichat; X-W Zhang; J Hashimoto; K Wiren; C Chenu
Journal:  Bone       Date:  2006-08-01       Impact factor: 4.398

9.  Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function.

Authors:  Francine Côté; Etienne Thévenot; Cécile Fligny; Yves Fromes; Michèle Darmon; Marie-Anne Ripoche; Elisa Bayard; Naima Hanoun; Francoise Saurini; Philippe Lechat; Luisa Dandolo; Michel Hamon; Jacques Mallet; Guilan Vodjdani
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-03       Impact factor: 11.205

10.  Acyclovir inhibits rat liver tryptophan-2,3-dioxygenase and induces a concomitant rise in brain serotonin and 5-hydroxyindole acetic acid levels.

Authors:  Adrienne C Müller; Santy Daya
Journal:  Metab Brain Dis       Date:  2008-07-30       Impact factor: 3.584
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.