Literature DB >> 600798

RNA methylation and control of eukaryotic RNA biosynthesis: processing and utilization of undermethylated tRNAs in CHO cells.

F Amalric, J P Bachellerie, M Caboche.   

Abstract

The role of RNA methylations in the control of tRNA production and utilization for protein biosynthesis has been investigated through a study of the effects in vivo of cycloleucine a specific and potent inhibitor of S adenosyl-methionine mediated methylation. During the cycloleucine treatment, the rate of appearance of newly synthetized tRNAs into the cytoplasm is markedly reduced (about 50%). These molecules are extensively (more than 90%) undermethylated and are integrated into polysomes, but at a slower rate than normally methylated tRNAs.

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Year:  1977        PMID： 600798      PMCID： PMC343246          DOI： 10.1093/nar/4.12.4357

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  17 in total

1.  Characterization of the 5' termini of hn RNA in mouse L cells: implications for processing and cap formation.

Authors:  U Schibler; R P Perry
Journal:  Cell       Date:  1976-09       Impact factor: 41.582

2.  tRNA synthesis in HeLa cells: a precursor to tRNA and the effects of methionine starvation on tRNA synthesis.

Authors:  D Bernhardt; J E Darnell
Journal:  J Mol Biol       Date:  1969-05-28       Impact factor: 5.469

3.  Expression of the mitochondrial genome in HeLa cells. XIX. Occurrence in mitochondria of polyadenylic acid sequences, "free" and covalently linked to mitochondrial DNA-coded RNA.

Authors:  D Ojala; G Attardi
Journal:  J Mol Biol       Date:  1974-01-15       Impact factor: 5.469

4.  Methylation and processing of transfer ribonucleic acid in mammalian and bacterial cells.

Authors:  T W Munns; H F Sims
Journal:  J Biol Chem       Date:  1975-03-25       Impact factor: 5.157

5.  RNA methylation and control of eukaryotic RNA biosynthesis. Effects of cycloleucine, a specific inhibitor of methylation, on ribosomal RNA maturation.

Authors:  M Caboche; J P Bachellerie
Journal:  Eur J Biochem       Date:  1977-03-15

Review 6.  Processing of RNA.

Authors:  R P Perry
Journal:  Annu Rev Biochem       Date:  1976       Impact factor: 23.643

Review 7.  The methylation of tRNA.

Authors:  F Nau
Journal:  Biochimie       Date:  1976       Impact factor: 4.079

8.  Drug effects on nucleic acid modification. I. A specific effect of 5-azacytidine on mammalian transfer RNA methylation in vivo.

Authors:  L W Lu; G H Chiang; D Medina; K Randerath
Journal:  Biochem Biophys Res Commun       Date:  1976-02-23       Impact factor: 3.575

9.  Methyldeficient mammalian 4s RNA: evidence for L-ethionine-induced inhibition of N6-dimethyladenosine synthesis in rat liver tRNA.

Authors:  D Wildenauer; H J Gross
Journal:  Nucleic Acids Res       Date:  1974-02       Impact factor: 16.971

10.  Alterations of tRNA modification in mammalian systems: the effect of ethionine.

Authors:  S Friedman
Journal:  Nucleic Acids Res       Date:  1977-06       Impact factor: 16.971
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  5 in total

1.  Evidence that the methylation inhibitor cycloleucine causes accumulation of a discrete ribosomal RNA precursor in hamster mitochondria.

Authors:  D L Prince; R M Kotin; D T Dubin
Journal:  Mol Biol Rep       Date:  1986       Impact factor: 2.316

2.  Synthesis and behaviour of small RNA species of CHO cells submitted to a heat chick.

Authors:  G Bouche; M Caizergues-Ferrer; F Amalric; J P Zalta; D Banville; R Simard
Journal:  Nucleic Acids Res       Date:  1981-04-10       Impact factor: 16.971

3.  Biosynthesis and utilization of extensively undermethylated poly(A)+ RNA in CHO cells during a cycloleucine treatment.

Authors:  J P Bachellerie; F Amalric; M Caboche
Journal:  Nucleic Acids Res       Date:  1978-08       Impact factor: 16.971

Review 4.  Molecular aspects of the in vivo and in vitro effects of ethionine, an analog of methionine.

Authors:  J H Alix
Journal:  Microbiol Rev       Date:  1982-09

5.  Expression of targeted ribozyme against telomerase RNA causes altered expression of several other genes in tumor cells.

Authors:  Suresh Kumar Ramakrishnan; Akhil Varshney; Amod Sharma; Bhudev C Das; Pramod K Yadava
Journal:  Tumour Biol       Date:  2014-03-25
  5 in total

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