| Literature DB >> 598843 |
Abstract
The effects of nitrofurantoin [N-(5-nitro-2-furfurylidine)-1-amino-hydantoin] on chromosomes of primary and secondary spermatocytes of mice were studied. No mutagenic activity was detectable after application of either 8 mg/kg or 40 mg/kg nitrofurantoin. An increase in the univalent rates and a decrease in the chiasma frequencies was observed in treated animals. The probable origins of these effects are discussed.Entities:
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Year: 1977 PMID： 598843 DOI： 10.1007/bf00295430
Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132