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Literature DB >> 598402

Effect of clonidine on sleep patterns in man.

A Autret, M Minz, T Beillevaire, H P Cathala, H Schmitt.

Abstract

Clonidine (300 microgram orally) increased in man the total duration of sleep and strikingly reduced the duration of REM sleep. Yohimbine (10 mg per os) did not alter the sleep patterns in man but antagonized the effects of clonidine. These results provide evidence that an alpha sympathomimetic mechanism could suppress REM sleep and increased the total duration of sleep.

Entities: Chemical Disease Species

Mesh：

Substances：
Yohimbine
Clonidine

Year: 1977 PMID： 598402 DOI： 10.1007/bf00562444

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

18 in total

1. A study of the central effects of sympathomimetic drugs: EEG and behavioural investigations on clonidine and naphazoline.

Authors: V Florio; L Bianchi; V G Lonogo
Journal: Neuropharmacology Date: 1975-10 Impact factor: 5.250

2. Different alpha-adrenoreceptors in the central nervous system mediating biochemical and functional effects of clonidine and receptor blocking agents.

Authors: N E Andén; M Grabowska; U Strömbom
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1976 Impact factor: 3.000

3. Sedative effects of alpha-sympathomimetic drugs and their antagonism by adrenergic and cholinergic blocking drugs.

Authors: B Delbarre; H Schmitt
Journal: Eur J Pharmacol Date: 1971 Impact factor: 4.432

4. Evidence for a central noradrenaline receptor stimulation by clonidine.

Authors: N E Andén; H Corrodi; K Fuxe; B Hökfelt; T Hökfelt; C Rydin; T Svensson
Journal: Life Sci Date: 1970-05-01 Impact factor: 5.037

5. Effects of some sympathomimetic amines administered intraventicularly on rabbit's EEG.

Authors: Y Matsuda
Journal: Jpn J Pharmacol Date: 1969-03

6. Possible involvement of central adrenaline neurons in vasomotor and respiratory control. Studies with clonidine and its interactions with piperoxane and yohimbine.

Authors: P Bolme; H Corrodi; K Fuxe; T Hökfelt; P Lidbrink; M Goldstein
Journal: Eur J Pharmacol Date: 1974-09 Impact factor: 4.432

Review 4. Are the pharmacology and physiology of α₂ adrenoceptors determined by α₂-heteroreceptors and autoreceptors respectively?

Authors: Ralf Gilsbach; Lutz Hein
Journal: Br J Pharmacol Date: 2012-01 Impact factor: 8.739

5. Effects of clonidine on breathing during sleep and susceptibility to central apnoea.

Authors: Abdul Ghani Sankri-Tarbichi; Kevin Grullon; M Safwan Badr
Journal: Respir Physiol Neurobiol Date: 2012-09-24 Impact factor: 1.931

Review 6. Melatonin supplementation for severe and intractable sleep disturbance in young people with genetically determined developmental disabilities: short review and commentary.

Authors: J Turk
Journal: J Med Genet Date: 2003-11 Impact factor: 6.318

7. Central effects of guanfacine and clonidine during wakefulness and sleep in healthy subjects.

Authors: R Spiegel; J E DeVos
Journal: Br J Clin Pharmacol Date: 1980 Impact factor: 4.335

7 in total

Effect of clonidine on sleep patterns in man.

1. A study of the central effects of sympathomimetic drugs: EEG and behavioural investigations on clonidine and naphazoline.

2. Different alpha-adrenoreceptors in the central nervous system mediating biochemical and functional effects of clonidine and receptor blocking agents.

3. Sedative effects of alpha-sympathomimetic drugs and their antagonism by adrenergic and cholinergic blocking drugs.

4. Evidence for a central noradrenaline receptor stimulation by clonidine.

5. Effects of some sympathomimetic amines administered intraventicularly on rabbit's EEG.

6. Possible involvement of central adrenaline neurons in vasomotor and respiratory control. Studies with clonidine and its interactions with piperoxane and yohimbine.

7. Central effects of clonidine 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride in fowls.

8. Effects of catecholamines and adenosine derivatives given into the brain of fowls.

9. Sleep produced by clonidine (2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride).

10. Human sleep and 5-HTP. Effects of repeated high doses and of association with benserazide (RO.04.4602).

1. α₂-Adrenergic blockade rescues hypoglossal motor defense against obstructive sleep apnea.

2. Clonidine has a paradoxical effect on cyclic arousal and sleep bruxism during NREM sleep.

3. 6-(3-chloro)-phenoxy-2-methyl-1-oxa-4-azospiro-[4,5]decane-3-one (CERM 3726) and sleep of healthy men.

Review 4. Are the pharmacology and physiology of α₂ adrenoceptors determined by α₂-heteroreceptors and autoreceptors respectively?

5. Effects of clonidine on breathing during sleep and susceptibility to central apnoea.

Review 6. Melatonin supplementation for severe and intractable sleep disturbance in young people with genetically determined developmental disabilities: short review and commentary.

7. Central effects of guanfacine and clonidine during wakefulness and sleep in healthy subjects.