| Literature DB >> 597772 |
C M Smith, L M Rovamo, K O Raivio.
Abstract
The mechanism of fructose-induced nucleotide catabolism was studied using isolated rat hepatocytes in which the adenine nucleotide pool was prelabelled with [14C]adenine. Incubation of these cells with fructose caused a rapid depletion of the adenine nucleotides and a corresponding increase in allantoin. There was no accumulation of radioactivity in adenosine in the presence or absence of the adenosine deaminase inhibitor 9-erythro-(2-hydroxy-3-nonyl)adenine. This confirms the previous hypothesis that fructose-induced adenine nucleotide catabolism occurs by way of AMP deaminase (AMP amino-hydrolase, EC 3.5.4.6).Entities:
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Year: 1977 PMID： 597772 DOI： 10.1139/o77-185
Source DB: PubMed Journal: Can J Biochem ISSN： 0008-4018