Literature DB >> 597671

Actions of 16-aryloxy analogues of prostaglandin F2alpha on preparations responsive to prostaglandin endoperoxides.

R L Jones, C G Marr.   

Abstract

On four prostaglandin endoperoxide-sensitive preparations, namely human platelets in vitro, rabbit aortic strip, guinea-pig tracheal chain and pig blood pressure, ICI 79939 and its 11-oxo analogue mimicked the actions of 11,9-(epoxymethano) prostaglandin H2, and were considerably more active than either prostaglandin F2alpha or ICI 81008. It is suggested that this activity of ICI 79939 may contribute to its toxicity in experimental animals.

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Year:  1977        PMID： 597671      PMCID： PMC1668060          DOI： 10.1111/j.1476-5381.1977.tb07563.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  4 in total

1.  The synthesis and biological activity of potent, selective luteolytic prostaglandins.

Authors:  N S Crossley
Journal:  Prostaglandins       Date:  1975-07

2.  Prostaglandin D2 inhibits the aggregation of human platelets.

Authors:  J B Smith; M J Silver; C M Ingerman; J J Kocsis
Journal:  Thromb Res       Date:  1974-09       Impact factor: 3.944

3.  Potent luteolytic agents related to prostaglandin F2alpha.

Authors:  M Dukes; W Russell; A L Walpole
Journal:  Nature       Date:  1974-07-26       Impact factor: 49.962

4.  Prostaglandin d2 as a potential antithrombotic agent.

Authors:  E E Nishizawa; W L Miller; R R Gorman; G L Bundy; J Svensson; M Hamberg
Journal:  Prostaglandins       Date:  1975-01
  4 in total
  6 in total

1.  Prostaglandin E receptor subtypes in smooth muscle: agonist activities of stable prostacyclin analogues.

Authors:  Y J Dong; R L Jones; N H Wilson
Journal:  Br J Pharmacol       Date:  1986-01       Impact factor: 8.739

2.  A 16-p-fluorophenoxy prostanoid with potent and long-lasting thromboxane-like actions [proceedings].

Authors:  R L Jones; N H Wilson
Journal:  Br J Pharmacol       Date:  1978-06       Impact factor: 8.739

3.  Antagonism of the thromboxane-sensitive contractile systems of the rabbit aorta, dog saphenous vein and guinea-pig trachea.

Authors:  R L Jones; V Peesapati; N H Wilson
Journal:  Br J Pharmacol       Date:  1982-07       Impact factor: 8.739

4.  EP 171: a high affinity thromboxane A2-mimetic, the actions of which are slowly reversed by receptor blockade.

Authors:  R L Jones; N H Wilson; R A Lawrence
Journal:  Br J Pharmacol       Date:  1989-04       Impact factor: 8.739

5.  Ligand binding to thromboxane receptors on human platelets: correlation with biological activity.

Authors:  R A Armstrong; R L Jones; N H Wilson
Journal:  Br J Pharmacol       Date:  1983-08       Impact factor: 8.739

6.  Pharmacological effects of (+/-)-11-deoxy, 16-phenoxy-prostaglandin E1 derivatives in the cardiovascular system.

Authors:  A K Banerjee; D P Tuffin; J L Walker
Journal:  Br J Pharmacol       Date:  1985-01       Impact factor: 8.739
  6 in total

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