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Literature DB >> 597275

A comparison of the effects of prednisolone and methylprednisolone on human lymphoblastoid cells.

Abstract

Methylprednisolone is more effective than prednisolone in mediating long-term cytolysis and immediate inhibition of nucleoside uptake in human lymphoblastoid cells. This suggests that methylation of prednisolone makes it more potent by aiding interaction with a cellular target rather than increasing its stability.

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Year: 1977 PMID： 597275 PMCID： PMC1183769 DOI： 10.1042/bj1680323

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

13 in total

1. Studies of structure-function relationships of steroids. II. The 6 alpha-methylcorticosteroids.

Authors: G W LIDDLE
Journal: Metabolism Date: 1958-07 Impact factor: 8.694

2. Inhibition of uridine uptake by methylprednisolone in human lymphoblastoid cells.

Authors: A W Waddell; C C Bird; A R Currie
Journal: Biochem Soc Trans Date: 1976 Impact factor: 5.407

3. The role of cytoplasmic glucocorticoid receptors in the cytolysis of human lymphoblastoid cells by methylprednisolone [proceedings].

Authors: A W Waddell; C C Bird; A R Currie
Journal: Biochem Soc Trans Date: 1977 Impact factor: 5.407

4. Substrate requirements and kinetic analysis of the cortisol effects on uridine uptake and incorporation by mouse lymphoma P1798 cells in vitro.

Authors: J Stevens; Y W Stevens; V P Hollander
Journal: Cancer Res Date: 1974-09 Impact factor: 12.701

Review 5. Estrogen-receptor interaction.

Authors: E V Jensen; E R DeSombre
Journal: Science Date: 1973-10-12 Impact factor: 47.728

A comparison of the effects of prednisolone and methylprednisolone on human lymphoblastoid cells.

1. Studies of structure-function relationships of steroids. II. The 6 alpha-methylcorticosteroids.

2. Inhibition of uridine uptake by methylprednisolone in human lymphoblastoid cells.

3. The role of cytoplasmic glucocorticoid receptors in the cytolysis of human lymphoblastoid cells by methylprednisolone [proceedings].

4. Substrate requirements and kinetic analysis of the cortisol effects on uridine uptake and incorporation by mouse lymphoma P1798 cells in vitro.

Review 5. Estrogen-receptor interaction.

6. Human lymphoblastoid cell lines. 3. Co-cultivation technique for establishment of new lines.

7. Glucocorticoids: competitive inhibition of glucose transport.

Review 8. Effects of corticosteroids on connective tissue and fibroblasts.

9. Combined drug treatment of Hodgkin's disease: remission induction, remission duration, and survival; an appraisal.

10. Cytoplasmic receptor levels and glucocorticoid response in human lymphoblastoid cell lines.

1. Relative immunosuppressive potency of various corticosteroids measured in vitro.