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Literature DB >> 597265

Immunological evaluation of repeated administration of erythrocyte-entrapped protein to C3H/HeJ mice.

Abstract

The immunogenicity of heterologous protein entrapped in autologous erythrocytes was evaluated in a mouse system. Multiple intravenous administrations of an erythrocyte-entrapped bovine beta-glucuronidase preparation resulted in little, if any, immunological response to the entrapped protein or erythrocyte carrier. Erythrocyte entrapment also protected protein from circulating antibody elicited by prior subcutaneous sensitization with unentrapped enzyme in adjuvant. Thus erythrocyte entrapment may protect potentially immunogenic agents from immunological surveillance.

Entities: Gene Species

Mesh：

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Year: 1977 PMID： 597265 PMCID： PMC1183745 DOI： 10.1042/bj1680141

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

12 in total

1. Enzyme therapy IV. A method for determining the in vivo fate of bovine beta-glucuronidase in beta-glucuronidase deficient mice.

Authors: S R Thorpe; M B Fiddler; R J Desnick
Journal: Biochem Biophys Res Commun Date: 1974-12-23 Impact factor: 3.575

2. Caveat to protein replacement therapy for genetic disease. Immunological implications of accurate molecular diagnosis.

Authors: S H Boyer; D C Siggers; L J Krueger
Journal: Lancet Date: 1973-09-22 Impact factor: 79.321

3. Recombinant inbred lines: value in the genetic analysis of biochemical variants.

Authors: R T Swank; D W Bailey
Journal: Science Date: 1973-09-28 Impact factor: 47.728

4. Enzyme therapy. Differential in vivo retention of bovine hepatic, renal, and splenic beta-glucuronidases and evidence for enzyme stabilization by intermolecular exchange.

Authors: M B Fiddler; R J Desnick
Journal: Arch Biochem Biophys Date: 1977-03 Impact factor: 4.013

1. Fabry disease: preclinical studies demonstrate the effectiveness of alpha-galactosidase A replacement in enzyme-deficient mice.

Authors: Y A Ioannou; K M Zeidner; R E Gordon; R J Desnick
Journal: Am J Hum Genet Date: 2000-12-13 Impact factor: 11.025

1 in total

Immunological evaluation of repeated administration of erythrocyte-entrapped protein to C3H/HeJ mice.

1. Enzyme therapy IV. A method for determining the in vivo fate of bovine beta-glucuronidase in beta-glucuronidase deficient mice.

2. Caveat to protein replacement therapy for genetic disease. Immunological implications of accurate molecular diagnosis.

3. Recombinant inbred lines: value in the genetic analysis of biochemical variants.

4. Enzyme therapy. Differential in vivo retention of bovine hepatic, renal, and splenic beta-glucuronidases and evidence for enzyme stabilization by intermolecular exchange.

5. A dialysis procedure for loading erythrocytes with enzymes and lipids.

Review 6. Toward enzyme therapy for lysosomal storage diseases.

7. Factors controlling the resealing of the membrane of human erythrocyte ghosts after hypotonic hemolysis.

8. Enzyme therapy. V. In vivo fate of erythrocyte-entrapped beta-glucuronidase in beta-glucuronidase-deficient mice.

9. Asparaginase entrapped in red blood cells: action and survival.

10. Enzyme replacement therapy in Gaucher's disease: a rapid, high-yield method for purification of glucocerebrosidase.

1. Fabry disease: preclinical studies demonstrate the effectiveness of alpha-galactosidase A replacement in enzyme-deficient mice.