Literature DB >> 597259

Energy-dependent uptake of arsenite by rat liver mitochondria.

E J Harris, F M Achenjang.   

Abstract

Uptake of arsenite by rat liver mitochondria is energy-dependent, as shown by comparing values without and with either uncoupling agent or respiratory inhibitor present. The uptake is inhibited by mersalyl and N-ethylmaleimide, which can be used as 'stopping' agents to obtain uptake kinetics. At 20 degrees C the process is nearly complete in 1 min. The relation between the quantity in the energized mitochondria and the applied concentration corresponds to at least two different modes of binding of the arsenite. Competition occurs between arsenite and other anions (for example, phosphate) for intramitochondrial accumulation.

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Year:  1977        PMID： 597259      PMCID： PMC1184124          DOI： 10.1042/bj1680129

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  8 in total

1.  The effect of arsenite on rat-liver mitochondria.

Authors:  A Csillag
Journal:  FEBS Lett       Date:  1971-10-01       Impact factor: 4.124

2.  On the mechanism of oxidative phosphorylation. II. Effects of arsenite alone and in combination with 2,3-dimercaptopropanol.

Authors:  A L FLUHARTY; D R SANADI
Journal:  J Biol Chem       Date:  1961-10       Impact factor: 5.157

3.  On the mechanism of oxidative phosphorylation. IV. Mitochondrial swelling caused by arsenite in combination with 2,3-dimercaptopropanol and by cadmium ion.

Authors:  A L FLUHARTY; D R SANADI
Journal:  Biochemistry       Date:  1962-03       Impact factor: 3.162

4.  Comparison of the effects of disulfiram and dimercaptopropanol arsenite on mitochondrial structure and function.

Authors:  I Hassinen; M Hallman
Journal:  Biochem Pharmacol       Date:  1967-11       Impact factor: 5.858

5.  The dependence on energy and K+ ions of the accumulation of glutamate by rat liver mitochondria.

Authors:  E J Harris; J A Bangham; J M Wimhurst
Journal:  Arch Biochem Biophys       Date:  1973-09       Impact factor: 4.013

6.  The effects of colloids on the appearance and substrate permeability of rat liver mitochondria.

Authors:  E J Harris; C Tate; J R Manger; J A Bangham
Journal:  J Bioenerg       Date:  1971-08

7.  Intramitochondrial substrate concentration as a factor controlling metabolism. The role of interanion competition.

Authors:  E J Harris; J R Manger
Journal:  Biochem J       Date:  1968-09       Impact factor: 3.857

8.  Inhibition of respiration under the control of azide uptake by mitochondria.

Authors:  F Palmieri; M Klingenberg
Journal:  Eur J Biochem       Date:  1967-06
  8 in total
  2 in total

1.  Ion permeability induction by the SH cross-linking reagents in rat liver mitochondria is inhibited by the free radical scavenger, butylhydroxytoluene.

Authors:  S A Novgorodov; E V Kultayeva; L S Yaguzhinsky; V V Lemeshko
Journal:  J Bioenerg Biomembr       Date:  1987-06       Impact factor: 2.945

2.  Mitochondrial diaphorases as NAD⁺ donors to segments of the citric acid cycle that support substrate-level phosphorylation yielding ATP during respiratory inhibition.

Authors:  Gergely Kiss; Csaba Konrad; Issa Pour-Ghaz; Josef J Mansour; Beáta Németh; Anatoly A Starkov; Vera Adam-Vizi; Christos Chinopoulos
Journal:  FASEB J       Date:  2014-01-03       Impact factor: 5.191
  2 in total

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