| Literature DB >> 596974 |
H C van Prroijen, G Vierwinden, J Wessels, C Haanen.
Abstract
The interaction of cytosine arabinoside (Ara-C) with human plasma proteins was investigated by means of ultrafiltration and ultracentrifugation. The results obtained with both methods did not differ significantly. Ara-C binding was studied at plasma levels within the therapeutic range (0.005-1.0 mg/l). It appeared that 13.3% (SD: 2.2%) of Ara-C in the plasma was bound to proteins. The percentage of bound drug was independent of the drug concentration, at least in the therapeutic range.Entities:
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Year: 1977 PMID： 596974
Source DB: PubMed Journal: Arch Int Pharmacodyn Ther ISSN： 0003-9780