Literature DB >> 5968554

Factors influencing the rate of "aging" of a series of alkyl methylphosphonyl-acetylcholinesterases.

W K Berry, D R Davies.   

Abstract

1. The progressive development of resistance to reactivation by an oxime (;aging') shown by a series of alkyl methylphosphonyl-acetylcholinesterases is slow when the alkyl group is a primary alcohol, whether or not the carbon chain is branched, but is much more rapid if the alkyl group is a secondary or cyclic alcohol. 2. Aging is accelerated by increase of temperature or decrease of pH. 3. Aging is inhibited by the quaternary amine N-methylpyridinium iodide. 4. The results are discussed in relation to the role played by aging in the therapy of poisoning by organophosphorus compounds.

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Year:  1966        PMID： 5968554      PMCID： PMC1265173          DOI： 10.1042/bj1000572

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  5 in total

1.  The mechanism of hydrolysis by cholinesterase and related enzymes.

Authors:  D R DAVIES; A L GREEN
Journal:  Adv Enzymol Relat Subj Biochem       Date:  1958

2.  Cholinesterase inhibition and the effect of anti-cholinesterases on indirectly evoked single and tetanic muscle contractions in the phrenic nerve-diaphragm preparation from the rat.

Authors:  J A BARSTAD
Journal:  Arch Int Pharmacodyn Ther       Date:  1960-10-01

3.  The reactivation of cholinesterase after Inhibition in vivo by some dimethyl phosphate esters.

Authors:  M VANDEKAR; D F HEATH
Journal:  Biochem J       Date:  1957-10       Impact factor: 3.857

4.  Chemical reactivation of phosphorylated human and bovine true cholinesterases.

Authors:  F HOBBIGER
Journal:  Br J Pharmacol Chemother       Date:  1956-09

5.  The kinetics of reactivation, by oximes, of cholinesterase inhibited by organophosphorus compounds.

Authors:  D R DAVIES; A L GREEN
Journal:  Biochem J       Date:  1956-08       Impact factor: 3.857
  5 in total
  13 in total

1.  Importance of aspartate-70 in organophosphate inhibition, oxime re-activation and aging of human butyrylcholinesterase.

Authors:  P Masson; M T Froment; C F Bartels; O Lockridge
Journal:  Biochem J       Date:  1997-07-01       Impact factor: 3.857

2.  Direct quantitation of methyl phosphonate adducts to human serum butyrylcholinesterase by immunomagnetic-UHPLC-MS/MS.

Authors:  Melissa D Carter; Brian S Crow; Brooke G Pantazides; Caroline M Watson; Jerry D Thomas; Thomas A Blake; Rudolph C Johnson
Journal:  Anal Chem       Date:  2013-11-08       Impact factor: 6.986

Review 3.  Efforts toward treatments against aging of organophosphorus-inhibited acetylcholinesterase.

Authors:  Qinggeng Zhuang; Amneh Young; Christopher S Callam; Craig A McElroy; Özlem Dogan Ekici; Ryan J Yoder; Christopher M Hadad
Journal:  Ann N Y Acad Sci       Date:  2016-06-21       Impact factor: 5.691

4.  Characterization of cholinesterases in various tissues of guinea pig with respect to their reactivation by obidoxime after inactivation by diisopropylfluorophosphate.

Authors:  C Alsen; F K Ohnesorge
Journal:  Arch Toxikol       Date:  1972

5.  [Effect of soman and diisopropylfluorophosphate upon enzyme biosynthesis in rat liver].

Authors:  W Domschke; G F Domagk; S Domschke; W D Erdmann
Journal:  Arch Toxikol       Date:  1970

6.  [Late effects upon respiration and circulation following successful treatment of paraoxone poisoning with cholinesterase reactivators and atropine in cats].

Authors:  G Schmidt; J Grützmacher
Journal:  Arch Toxikol       Date:  1969

7.  Methantheline improves the reactivation by HI 6 of human erythrocyte acetylcholinesterase inhibited by soman in vitro.

Authors:  M Hallek; L Szinicz
Journal:  Arch Toxicol       Date:  1995       Impact factor: 5.153

8.  A high-throughput UHPLC-MS/MS method for the quantification of five aged butyrylcholinesterase biomarkers from human exposure to organophosphorus nerve agents.

Authors:  Leigh Ann Graham; Darryl Johnson; Melissa D Carter; Emily G Stout; Huseyin A Erol; Samantha L Isenberg; Thomas P Mathews; Jerry D Thomas; Rudolph C Johnson
Journal:  Biomed Chromatogr       Date:  2016-10-09       Impact factor: 1.902

9.  Effect of pyridostigmine pretreatment, HI-6 and Toxogonin treatment on rat tracheal smooth muscle response to cholinergic stimulation after organophosphorus inhalation exposure.

Authors:  P Walday; P Aas; T Haider; F Fonnum
Journal:  Arch Toxicol       Date:  1993       Impact factor: 5.153

10.  [Inhibition of cholinesterase activity in erythrocytes, ventricular muscle and brain of guinea pigs by subchronic and acute poisoning with diisopropylphosphofluoridate (DFP) and its reactivation of obidoxime].

Authors:  F K Ohnesorge
Journal:  Arch Toxikol       Date:  1970
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