Immunological investigations of antigenicity and specificity of soluble collagen fractions. IV. Anaphylaxis and allergy experiments.

Collagen prepared from rat, calf, or pig skin was tested on guinea pigs for active cutaneous anaphylaxis. Only one fraction of calf skin collagen gave a slight, positive reaction. No positive reactions were observed in 21 subjects submitted to patch tests and 12 subjects submitted to scratch tests with pig skin collagen. Therefore preparations of pig skin collagen may be used for wound treatment without any risk.