Literature DB >> 5964967

Inhibitory effect of salicylate on the incorporation of L-(U-14C)leucine into the protein of rat tissue preparations in vitro.

P D Dawkins, B J Gould, M J Smith.   

Abstract

1. The inhibitory effect of salicylate, in concentrations ranging from 0.1 to 20mm, on the incorporation of radioactivity from l-[U-(14)C]leucine into the protein of isolated rat diaphragm muscle and of cell-free systems from rat liver was studied. 2. The lowest salicylate concentrations producing significant inhibitions of amino acid incorporation were as follows: isolated rat diaphragm, 0.1mm; rat-liver mitochondrial-microsomal system, 0.1mm; rat-liver microsomal system, 0.3mm. 3. Salicylate concentrations of 2.5mm and above were found to inhibit creatine-kinase activity in vitro.

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Year:  1966        PMID： 5964967      PMCID： PMC1265061          DOI： 10.1042/bj0990703

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  8 in total

1.  IN VITRO EFFECT OF SALICYLATE ON AMINO ACID ACCUMULATION BY KIDNEY CORTEX SLICES.

Authors:  S SEGAL; A BLAIR
Journal:  Nature       Date:  1963-10-12       Impact factor: 49.962

2.  Carbohydrate metabolism in experimental salicylism.

Authors:  R W WINTERS; M F MORRILL
Journal:  Proc Soc Exp Biol Med       Date:  1955-03

3.  Effects of salicylate on amino acid incorporation into protein.

Authors:  W P WEISS; P L CAMPBELL; G E DEIBLER; L SOKOLOFF
Journal:  J Pharmacol Exp Ther       Date:  1962-06       Impact factor: 4.030

4.  The action of thyroid hormones at the cell level.

Authors:  J R TATA; L ERNSTER; O LINDBERG; E ARRHENIUS; S PEDERSEN; R HEDMAN
Journal:  Biochem J       Date:  1963-03       Impact factor: 3.857

5.  Serum amino acid nitrogen in infancy and childhood.

Authors:  B F ANDREWS; O C BRUTON; L DE BAARE
Journal:  J Pediatr       Date:  1962-02       Impact factor: 4.406

6.  Some effects of sodium salicylate on muscle metabolism.

Authors:  K L MANCHESTER; P J RANDLE; G H SMITH
Journal:  Br Med J       Date:  1958-05-03

7.  Action of sodium salicylate and related compounds on tissue metabolism in vitro.

Authors:  T M BRODY
Journal:  J Pharmacol Exp Ther       Date:  1956-05       Impact factor: 4.030

8.  The estimation of creatine and of diacetyl.

Authors:  P Eggleton; S R Elsden; N Gough
Journal:  Biochem J       Date:  1943       Impact factor: 3.857
  8 in total
  4 in total

1.  Impairment of protein synthesis in the rat uterus following intrauterine delivery of indomethacin.

Authors:  P R Hurst; P V Peplow
Journal:  Br J Pharmacol       Date:  1986-09       Impact factor: 8.739

2.  The effect of salicylate on the metabolism of normal and stimulated human lymphocytes in vitro.

Authors:  L M Pachman; N B Esterly; R D Peterson
Journal:  J Clin Invest       Date:  1971-01       Impact factor: 14.808

3.  Inhibition of protein biosynthesis by salicylate in gastric-mucosal scrapings of pig and man in vitro.

Authors:  K D Rainsford; M J Smith
Journal:  Biochem J       Date:  1969-03       Impact factor: 3.857

4.  Effect of salicylates on histamine and L-histidine metabolism. Inhibition of imidazoleacetate phosphoribosyl transferase.

Authors:  J Moss; M C De Mello; M Vaughan; M A Beaven
Journal:  J Clin Invest       Date:  1976-07       Impact factor: 14.808
  4 in total

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