Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Release of enzymes from lysosomes by irradiation and the relation of lipid peroxide formation to enzyme release.

Literature DB >> 5964962

Release of enzymes from lysosomes by irradiation and the relation of lipid peroxide formation to enzyme release.

Abstract

1. Acid phosphatase, cathepsin and beta-glucuronidase are released from rat-liver lysosomes by irradiation in vitro. Enzyme release is detectable after a dose of 1krad and increases with dose up to 100krads. 2. Maximum radiation effects were observed when the lysosomes were kept for 20hr. at 4 degrees or 20 degrees after irradiation. 3. An atmosphere of nitrogen considerably decreases enzyme release from lysosomes. 4. Enzyme release is enhanced by ascorbic acid and decreased by vitamin E. 5. Irradiation causes formation of lipid peroxides in lysosomes, and enzyme release increases with lipid peroxide formation. 6. It is suggested that lipid peroxide formation leads to rupture of the lysosome membrane and allows release of the contained hydrolytic enzymes.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1966 PMID： 5964962 PMCID： PMC1265055 DOI： 10.1042/bj0990657

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

18 in total

1. LYSOSOME PARTICLES AND SUBCELLULAR DISTRIBUTIONS OF POLYMERIC TETRAVALENT PLUTONIUM-239.

Authors: Y E RAHMAN; A LINDENBAUM
Journal: Radiat Res Date: 1964-04 Impact factor: 2.841

2. THE EFFECT OF INORGANIC IRON ON THE THIOBARBITURIC ACID METHOD FOR THE DETERMINATION OF LIPID PEROXIDES.

Authors: E D WILLS
Journal: Biochim Biophys Acta Date: 1964-08-05

3. Tissue fractionation studies. 4. Comparative study of the binding of acid phosphatase, beta-glucuronidase and cathepsin by rat-liver particles.

Authors: R GIANETTO; C DE DUVE
Journal: Biochem J Date: 1955-03 Impact factor: 3.857

4. The protective action of tocopherol against hemolysis of rat erythrocytes by dialuric acid.

Authors: C C TSEN; H B COLLIER
Journal: Can J Biochem Physiol Date: 1960-09

5. Lipid peroxide formation in regenerating rat liver.

Authors: N WOLFSON; K M WILBUR; F BERNHEIM
Journal: Exp Cell Res Date: 1956-04 Impact factor: 3.905

6. Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue.

Authors: C DE DUVE; B C PRESSMAN; R GIANETTO; R WATTIAUX; F APPELMANS
Journal: Biochem J Date: 1955-08 Impact factor: 3.857

7. AN " ACID " PHOSPHATASE OCCURRING IN THE SERUM OF PATIENTS WITH METASTASIZING CARCINOMA OF THE PROSTATE GLAND.

Authors: A B Gutman; E B Gutman
Journal: J Clin Invest Date: 1938-07 Impact factor: 14.808

8. A microspectrophotometric method for the determination of cytochrome oxidase.

Authors: S J COOPERSTEIN; A LAZAROW
Journal: J Biol Chem Date: 1951-04 Impact factor: 5.157

9. The thiobarbituric acid reagent as a test for the oxidation of unsaturated fatty acids by various agents.

Authors: K M WILBUR; F BERNHEIM; O W SHAPIRO
Journal: Arch Biochem Date: 1949-12

10. Effect of gamma irradiation on the desoxyribonuclease II activity of isolated mitochondria.

Authors: S OKADA; L D PEACHY
Journal: J Biophys Biochem Cytol Date: 1957-03-25

26 in total

1. Formation of lipoperoxide in the retina of rabbit exposed to high concentration of oxygen.

Authors: T Hiramitsu; Y Hasegawa; K Hirata; I Nishigaki; K Yagi
Journal: Experientia Date: 1976-05-15

Review 2. Experimental intestinal malabsorption states and their relation to clinical syndromes.

Authors: J W Robinson
Journal: Klin Wochenschr Date: 1972-02-15

3. [On the formation of cytoplasmic vacuoles of leucocytes in vitro. II. Formation of cytoplasmic vacuoles in dependence on the experimental influence on the stability of membranes (author's transl)].

Authors: C Eschenbach; G Seebach
Journal: Klin Wochenschr Date: 1974-07-15

Release of enzymes from lysosomes by irradiation and the relation of lipid peroxide formation to enzyme release.

1. LYSOSOME PARTICLES AND SUBCELLULAR DISTRIBUTIONS OF POLYMERIC TETRAVALENT PLUTONIUM-239.

2. THE EFFECT OF INORGANIC IRON ON THE THIOBARBITURIC ACID METHOD FOR THE DETERMINATION OF LIPID PEROXIDES.

3. Tissue fractionation studies. 4. Comparative study of the binding of acid phosphatase, beta-glucuronidase and cathepsin by rat-liver particles.

4. The protective action of tocopherol against hemolysis of rat erythrocytes by dialuric acid.

5. Lipid peroxide formation in regenerating rat liver.

6. Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue.

7. AN " ACID " PHOSPHATASE OCCURRING IN THE SERUM OF PATIENTS WITH METASTASIZING CARCINOMA OF THE PROSTATE GLAND.

8. A microspectrophotometric method for the determination of cytochrome oxidase.

9. The thiobarbituric acid reagent as a test for the oxidation of unsaturated fatty acids by various agents.

10. Effect of gamma irradiation on the desoxyribonuclease II activity of isolated mitochondria.

1. Formation of lipoperoxide in the retina of rabbit exposed to high concentration of oxygen.

Review 2. Experimental intestinal malabsorption states and their relation to clinical syndromes.

3. [On the formation of cytoplasmic vacuoles of leucocytes in vitro. II. Formation of cytoplasmic vacuoles in dependence on the experimental influence on the stability of membranes (author's transl)].

4. NADPH and ascorbate catalyzed peroxidation of microsomal lipids during ageing.

5. Effects of iron-containing substances on nervous tissue in vitro.

6. Lysosomes in the pathogenesis of the renal necrosis of choline-deficient rats.

7. Lipids of alveolar macrophages, polymorphonuclear leukocytes, and their phagocytic vesicles.

8. Unique radiosensitivity of serous cells in rhesus monkey submandibular glands.

9. Glutathione-dependent peroxidative metabolism in the alveolar macrophage.

10. Lipid peroxide formation in microsomes. General considerations.