Literature DB >> 594939

A kinetic study of lung DNA-synthesis during simulated chronic high altitude hypoxia.

N Völkel, U Wiegers, V Sill, J Trautmann.   

Abstract

Rats were exposed to crhonic hypobaric hypoxia at a simulated altitude of 4250 m for 3, 6, 9, 12, 20, and 35 days. The in-vitro incorporation of 3H-thymidine into the DNA of lung tissue was measured and compared with that of normoxic controls: the obtained time course study showed a maximum increase of 345% on the ninth day of hypoxia, indicating a marked stimulation of cellular proliferation. Between the 12th and 20th day of hypoxia, the lung DNA-synthesis reached control values. No significant change in the DNA-concentration of the lungs was registered. The response to hypoxia was less impressive in rat livers used as controls.

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Year:  1977        PMID： 594939      PMCID： PMC470793          DOI： 10.1136/thx.32.5.578

Source DB:  PubMed          Journal:  Thorax        ISSN： 0040-6376            Impact factor:   9.139


  12 in total

1.  The muscular pulmonary arteries in people native to high altitude.

Authors:  J ARIAS-STELLA; M SALDANA
Journal:  Med Thorac       Date:  1962

2.  Hypoxemia, effects on the pulmonary vascular bed.

Authors:  R L NAEYE
Journal:  Med Thorac       Date:  1962

3.  Pulmonary hypertention and right ventricular hypertrophy in catle at high altitude.

Authors:  A F ALEXANDER; D H WILL; R F GROVER; J T REEVES
Journal:  Am J Vet Res       Date:  1960-03       Impact factor: 1.156

4.  Molecular basis of a control mechanism of DNA synthesis in mammalian cells.

Authors:  A M Novi
Journal:  Klin Wochenschr       Date:  1976-10-15

5.  Effect of chronic hypoxia on the pulmonary arterial blood pressure of the chicken.

Authors:  R R Burton; E L Besch; A H Smith
Journal:  Am J Physiol       Date:  1968-06

6.  Cardiopulmonary responses of male and female swine to simulated high altitude.

Authors:  I F McMurtry; C H Frith; D H Will
Journal:  J Appl Physiol       Date:  1973-10       Impact factor: 3.531

7.  Effect of 7 per cent CO2 breathing on muscular pulmonary arteries and on the right ventricle in rats.

Authors:  S T Lodi; R Viswanathan
Journal:  Respiration       Date:  1974       Impact factor: 3.580

8.  Physiological responses of rats to intermittent high-altitude stress: effects of age.

Authors:  J J McGrath; J Procházka; V Pelouch; B Ostádal
Journal:  J Appl Physiol       Date:  1973-03       Impact factor: 3.531

9.  [Effects of propranolol on pulmonary hypertension, right ventricular hypertrophy and metabolic myocardial changes due to acute hypoxemia due to high altitude].

Authors:  P R Moret; F Duchosal
Journal:  Schweiz Med Wochenschr       Date:  1976-11-06

10.  Hypoxia and lung mast cells: influence of disodium cromoglycate.

Authors:  I P Mungall
Journal:  Thorax       Date:  1976-02       Impact factor: 9.139
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  6 in total

1.  Hypoxia-induced pulmonary vascular remodeling: a model for what human disease?

Authors:  N F Voelkel; R M Tuder
Journal:  J Clin Invest       Date:  2000-09       Impact factor: 14.808

2.  Accumulation of histamine and cyclic nucleotides in lung tissue during chronic hypobaric hypoxia.

Authors:  N Völkel; E Kaukel; J Trautmann
Journal:  Lung       Date:  1978       Impact factor: 2.584

3.  Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide.

Authors:  R M Tuder; B E Flook; N F Voelkel
Journal:  J Clin Invest       Date:  1995-04       Impact factor: 14.808

4.  PAF receptor blockade inhibits lung vascular changes in the rat monocrotaline model.

Authors:  S Ono; N F Voelkel
Journal:  Lung       Date:  1992       Impact factor: 2.584

5.  Hypoxia and incorporation of 3H-thymidine by cells of the rat pulmonary arteries and alveolar wall.

Authors:  B Meyrick; L Reid
Journal:  Am J Pathol       Date:  1979-07       Impact factor: 4.307

6.  Resident cell lineages are preserved in pulmonary vascular remodeling.

Authors:  Slaven Crnkovic; Leigh M Marsh; Elie El Agha; Robert Voswinckel; Bahil Ghanim; Walter Klepetko; Elvira Stacher-Priehse; Horst Olschewski; Wilhelm Bloch; Saverio Bellusci; Andrea Olschewski; Grazyna Kwapiszewska
Journal:  J Pathol       Date:  2018-03-09       Impact factor: 7.996
  6 in total

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