Literature DB >> 5949342

Neurological defect: manganese in phenocopy and prevention of a genetic abnormality of inner ear.

L Erway, L S Hurley, A Fraser.   

Abstract

A specific congenital ataxia may be caused by presence of mutant genes and by manganese deficiency during prenatal development in normal mice. Supplementation of the diet of mutant mice with manganese during prenatal development rectifies the aberrant development, resulting in normal behavior. The congential ataxa results from defective development of the the otoliths.

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Year:  1966        PMID： 5949342     DOI： 10.1126/science.152.3730.1766

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  8 in total

1.  Effects of calcium preloading on the growth of calcium carbonate crystals in the endolymphatic sac of the tree frog, Hyla arborea japonica.

Authors:  S Kawamata
Journal:  Cell Tissue Res       Date:  1988-06       Impact factor: 5.249

Review 2.  Inherited diseases of the inner ear in man in the light of studies on the mouse.

Authors:  M S Deol
Journal:  J Med Genet       Date:  1968-06       Impact factor: 6.318

3.  Genetic aspects of negative geotaxis in mice.

Authors:  G Lindzey; D D Thiessen
Journal:  Behav Genet       Date:  1970-02       Impact factor: 2.805

4.  Unilateral agenesis of the diaphragm.

Authors:  E Passarge; H Halsey; J German
Journal:  Humangenetik       Date:  1968

5.  The effects of manganese deficiency during prenatal and postnatal development on mitochondrial structure and function in the rat.

Authors:  S Zidenberg-Cherr; C L Keen; L S Hurley
Journal:  Biol Trace Elem Res       Date:  1985-02       Impact factor: 3.738

6.  Slow turnover of manganese in active rheumatoid arthritis accelerated by prednisone.

Authors:  G C Cotzias; P S Papavasiliou; E R Hughes; L Tang; D C Borg
Journal:  J Clin Invest       Date:  1968-05       Impact factor: 14.808

7.  Hyperoxia and hypoxia in pregnancy: simple experimental manipulation alters the incidence of cleft lip and palate in CL/Fr mice.

Authors:  G Millicovsky; M C Johnston
Journal:  Proc Natl Acad Sci U S A       Date:  1981-09       Impact factor: 11.205

8.  Deletion mapping of the head tilt (het) gene in mice: a vestibular mutation causing specific absence of otoliths.

Authors:  R A Bergstrom; Y You; L C Erway; M F Lyon; J C Schimenti
Journal:  Genetics       Date:  1998-10       Impact factor: 4.562
  8 in total

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