Literature DB >> 594368

Dose dependent inhibition of B-16 melanoma growth in vivo by a synthetic analogue of PGE2.

M G Santoro, G W Philpott, B M Jaffe.   

Abstract

Daily intratumor administration of 16,16-dimethyl-PGE2-methyl ester in two different dosages inhibited tumor growth in C57Bl/6J mice bearing subcutaneous B-16 melanomas. The larger dose (20 microgram/day/mouse) produced a 68% decrease in tumor volume, a 69% decrease in tumor weight and a 60% decrease in the number of cells in mitotic phase. The smaller dose (10microgram/day/mouse) was one fifth less effective than the 20microgram dose but produced similar changes. Histological examination of tumors revealed no significant differences either in the inflammatory cell population or the amount of necrosis in the control and di-M-PGE2-treated tumors.

Entities:  

Mesh：

Substances：

Year:  1977        PMID： 594368     DOI： 10.1016/0090-6980(77)90191-5

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  8 in total

1.  The influence of irradiation on the biological half-life of prostacyclin in plasma of patients with gastrointestinal cancer.

Authors:  P Polterauer; H Sinzinger; B A Peskar
Journal:  Br J Exp Pathol       Date:  1987-10

2.  Effect of non-steroidal anti-inflammatory drugs of Moloney sarcoma virus inoculated mice.

Authors:  A D Inglot; E Oleszak
Journal:  Experientia       Date:  1978-12-15

3.  Influence of zymosan (a non-specific macrophage stimulator) and of indomethacin on liver tumours--an experimental study in rats.

Authors:  S B Holmberg; P L Naredi; G O Lindnér; I H Karlberg; P L Daneryd; L M Karlsson; A Pettersson; U Stenram; L R Hafström
Journal:  J Cancer Res Clin Oncol       Date:  1995       Impact factor: 4.553

4.  Inhibition of tumor growth and metastasis by chronic intravenous infusion of prostaglandin E1.

Authors:  L M Ellis; E M Copeland; K I Bland; H S Sitren
Journal:  Ann Surg       Date:  1990-07       Impact factor: 12.969

5.  A clinical study of nafazatrom in advanced human breast cancer.

Authors:  A L Jones; T J Powles; G V Forgeson; R C Coombes
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333

6.  Effect of endogenous and exogenous prostaglandin E on Friend erythroleukaemia cell growth and differentiation.

Authors:  M G Santoro; A Benedetto; B M Jaffe
Journal:  Br J Cancer       Date:  1979-03       Impact factor: 7.640

7.  Inhibition of Friend erythroleukaemia-cell tumours in vivo by a synthetic analogue of prostaglandin E2.

Authors:  M G Santoro; B M Jaffe
Journal:  Br J Cancer       Date:  1979-04       Impact factor: 7.640

8.  Influence of prostaglandin analogues on epithelial cell proliferation and xenograft growth.

Authors:  P J Tutton; D H Barkla
Journal:  Br J Cancer       Date:  1980-01       Impact factor: 7.640
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.