Literature DB >> 5941784

Characterization of the renin-antirenin system.

B Warren, A G Johnson, S W Hoobler.   

Abstract

Rabbit antibody capable of neutralizing the pressor activity of the enzyme renin, derived from hog kidneys, was characterized with respect to type and capacity to react serologically. Three antirenin antibodies were detected, both a precipitating and nonprecipitating, neutralizing antibody as well as a neutralizing antibody capable of being absorbed by inactivated renin. The precipitating, neutralizing antibody was purified and used successfully in an assay for hog renin by means of a hemagglutination inhibition test. By immunofluorescent methods utilizing the purified antiserum, renin was found to be localized in the macula densa of the distal convoluted tubules and the juxtaglomerular cells of the afferent arteriole in both hog and dog kidneys.

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Year:  1966        PMID： 5941784      PMCID： PMC2138182          DOI： 10.1084/jem.123.6.1109

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  22 in total

1.  Effects of ganglionic blocking agents, pressor and depressor drugs on renal hypertension.

Authors:  E HAAS; H GOLDBLATT
Journal:  Am J Physiol       Date:  1959-12

2.  A rapid method for separating glomeruli from rabbit kidney.

Authors:  W F COOK; G W PICKERING
Journal:  Nature       Date:  1958-10-18       Impact factor: 49.962

3.  A simple fractionation method for preparation of fluorescein-labeled gamma globulin.

Authors:  J L RIGGS; P C LOH; W C EVELAND
Journal:  Proc Soc Exp Biol Med       Date:  1960-12

4.  JUXTAGLOMERULAR CELLS AS THE SOURCE OF RENIN: FURTHER STUDIES WITH THE FLUORESCENT ANTIBODY TECHNIQUE AND THE EFFECT OF PASSIVE TRANSFER OF ANTIRENIN.

Authors:  P M HARTROFT; L E SUTHERLAND; W S HARTROFT
Journal:  Can Med Assoc J       Date:  1964-01-25       Impact factor: 8.262

5.  Renin and antirenin in treatment of long term experimental renal hypertension in the dog.

Authors:  S H KREMEN; G E WAKERLIN
Journal:  Proc Soc Exp Biol Med       Date:  1955-10

6.  Physiological properties of renin and hypertension.

Authors:  H GOLDBLATT; H LAMFROM; E HAAS
Journal:  Am J Physiol       Date:  1953-10

7.  The effect of complement in rabbit serum on the quantitative precipitin reaction. I.

Authors:  P H MAURER; D W TALMAGE
Journal:  J Immunol       Date:  1953-02       Impact factor: 5.422

8.  Studies on fluorescent antibody staining. I. Non-specific fluorescence with fluorescein-coupled sheep anti-rabbit globulins.

Authors:  G GOLDSTEIN; I S SLIZYS; M W CHASE
Journal:  J Exp Med       Date:  1961-07-01       Impact factor: 14.307

9.  STUDIES ON EXPERIMENTAL HYPERTENSION : XX. THE BIOASSAY OF RENIN.

Authors:  H Goldblatt; Y J Katz; H A Lewis; E Richardson
Journal:  J Exp Med       Date:  1943-04-01       Impact factor: 14.307

10.  A STUDY OF THE COMPETITION OF LECITHIN AND ANTITOXIN FOR CL. WELCHII LECITHINASE.

Authors:  P C Zamecnik; F Lipmann
Journal:  J Exp Med       Date:  1947-03-31       Impact factor: 14.307
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  4 in total

1.  A comparison of the properties of renin isolated from pig and rat kidney.

Authors:  M Lauritzen; J J Damsgaard; I Rubin; E Lauritzen
Journal:  Biochem J       Date:  1976-05-01       Impact factor: 3.857

Review 2.  [Renin-angiotensin-aldosterone system from the pathophysiological viewpoint].

Authors:  C Werning; W Siegenthaler
Journal:  Klin Wochenschr       Date:  1969-12-01

3.  [Adrenaline and noradrenaline excretion during angiotensin II infusions into the carotid artery of anesthetized dogs].

Authors:  C Werning; M Schönbeck; W H Ziegler; K Baumann; E Gysling; P Weidmann; W Siegenthaler
Journal:  Klin Wochenschr       Date:  1969-06-15

4.  Studies on the human renin--anti-renin system.

Authors:  B Warren; M Dolinski
Journal:  Immunology       Date:  1969-02       Impact factor: 7.397
  4 in total

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