Inheritance of reacitivity to experimental manipulation in mice.

The mode of inheritance of open-field defecation was found to differ according to earlier treatment of the mice. Activity of hybrids, however, was closer to that of the less active parent for all conditions of pretreatment. These results suggest that adequate sampling not only of gene pools, but also of both pretest and test environments, is necessary before statements concerning effects of prior treatment, or mode of inheritance of specific behavior, are valid.