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Literature DB >> 593884

Intramolecular base composition heterogeneity of human DNA.

D L Vizard, F P Rinehart, C M Rubin, C W Schmid.

Abstract

The intramolecular base composition heterogeneity of human DNA has been investigated by electron microscopic observations of partially denatured structures and by equilibrium solution thermal denaturation techniques. DNA sequences having an average length of less than 2000 base pairs are found to be heterogeneous in base composition. These heterogeneous sequences occupy a minimum of 67 to 81% of the human genome.

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Year: 1977 PMID： 593884 PMCID： PMC343198 DOI： 10.1093/nar/4.11.3753

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

17 in total

1. On the factors controlling the reversibility of DNA denaturation.

Authors: E P GEIDUSCHEK
Journal: J Mol Biol Date: 1962-06 Impact factor: 5.469

2. Sequence organization of the human genome.

Authors: C W Schmid; P L Deininger
Journal: Cell Date: 1975-11 Impact factor: 41.582

3. A STATISTICAL ANALYSIS OF DEOXYRIBONUCLEIC ACID DISTRIBUTION IN DENSITY GRADIENT CENTRIFUGATION.

Authors: N Sueoka
Journal: Proc Natl Acad Sci U S A Date: 1959-10 Impact factor: 11.205

4. An electron microscope study of the DNA sequence organization of the human genome.

Authors: P L Deininger; C W Schmid
Journal: J Mol Biol Date: 1976-09-25 Impact factor: 5.469

5. Bacteriophage T7 DNA replication: a linear replicating intermediate (gradient centrifugation-electron microscopy-E. coli-DNA partial denaturation).

Authors: J Wolfson; D Dressler; M Magazin
Journal: Proc Natl Acad Sci U S A Date: 1972-02 Impact factor: 11.205

Intramolecular base composition heterogeneity of human DNA.

1. On the factors controlling the reversibility of DNA denaturation.

2. Sequence organization of the human genome.

3. A STATISTICAL ANALYSIS OF DEOXYRIBONUCLEIC ACID DISTRIBUTION IN DENSITY GRADIENT CENTRIFUGATION.

4. An electron microscope study of the DNA sequence organization of the human genome.

5. Bacteriophage T7 DNA replication: a linear replicating intermediate (gradient centrifugation-electron microscopy-E. coli-DNA partial denaturation).

6. Populations of repeated DNA sequences in the human genome.

7. An analysis of eukaryotic genomes by density gradient centrifugation.

8. An approach to the organization of eukaryotic genomes at a macromolecular level.

9. Contrasting patterns of DNA sequence arrangement in Apis mellifera (honeybee) and Musca domestica (housefly).

10. Interspersion of repetitive and nonrepetitive DNA sequences in the Drosophila melanogaster genome.

1. Systematic punctuation of eukaryotic DNA by A+T-rich sequences.