Literature DB >> 5937128

Chloroquine: physiological basis of drug resistance in Plasmodium berghei.

P B Macomber, R L O'Brien, F E Hahn.   

Abstract

Mouse erythrocytes, parasitized by chloroquine-sensitive plasmodia, concentrate this drug in vivo to levels over twice as high as erythrocytes parasitized by chloroquine-resistant plasmodia; nonparasitized red cells accumulate little chloroquine. Selective toxicity of this drug may depend upon a special drug-concentrating mechanism of plasmodic impairment of such mechanism.

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Year:  1966        PMID： 5937128     DOI： 10.1126/science.152.3727.1374

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  18 in total

1.  Evidence that mutant PfCRT facilitates the transmission to mosquitoes of chloroquine-treated Plasmodium gametocytes.

Authors:  Andrea Ecker; Viswanathan Lakshmanan; Photini Sinnis; Isabelle Coppens; David A Fidock
Journal:  J Infect Dis       Date:  2011-01-15       Impact factor: 5.226

Review 2.  Involvement of heme in the antimalarial action of chloroquine.

Authors:  C D Fitch
Journal:  Trans Am Clin Climatol Assoc       Date:  1998

Review 3.  Antimalarial drugs and their actions.

Authors:  W Peters
Journal:  Postgrad Med J       Date:  1973-08       Impact factor: 2.401

Review 4.  [Biochemistry of some parasitic helminths and protozoa and the mode of action of some antiparasitic drugs].

Authors:  H Metzger
Journal:  Z Parasitenkd       Date:  1970

5.  Regulation of heme polymerizing activity and the antimalarial action of chloroquine.

Authors:  C D Fitch; A C Chou
Journal:  Antimicrob Agents Chemother       Date:  1997-11       Impact factor: 5.191

6.  Chloroquine uptake by Plasmodium falciparum-infected human erythrocytes during in vitro culture and its relationship to chloroquine resistance.

Authors:  F Verdier; J Le Bras; F Clavier; I Hatin; M C Blayo
Journal:  Antimicrob Agents Chemother       Date:  1985-04       Impact factor: 5.191

7.  Chloroquine resistance in malaria: accessibility of drug receptors to mefloquine.

Authors:  C D Fitch; R L Chan; R Chevli
Journal:  Antimicrob Agents Chemother       Date:  1979-02       Impact factor: 5.191

8.  Erythrocyte surface: novel determinant of drug susceptibility in rodent malaria.

Authors:  C D Fitch; R C Ng; R Chevli
Journal:  Antimicrob Agents Chemother       Date:  1978-08       Impact factor: 5.191

9.  Activities of various 4-aminoquinolines against infections with chloroquine-resistant strains of Plasmodium falciparum.

Authors:  L H Schmidt; D Vaughan; D Mueller; R Crosby; R Hamilton
Journal:  Antimicrob Agents Chemother       Date:  1977-05       Impact factor: 5.191

10.  Chloroquine resistance in malaria: a deficiency of chloroquine binding.

Authors:  C D Fitch
Journal:  Proc Natl Acad Sci U S A       Date:  1969-12       Impact factor: 11.205
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