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Literature DB >> 5933468

An antiviral substance from Penicillium funiculosum. V. Induction of interferon by helenine.

Abstract

Helenine, a substance obtained from broth cultures of Penicillium funiculosum and known to exert a protective effect in vivo in experimental animals against several unrelated viruses, has been shown to elicit the formation in cell cultures and in intact mice of an inhibitor of viral plaque formation. Because the biological and chemical characteristics of the viral inhibitor induced by helenine are similar to those of interferon, it is suggested that the antiviral effect of helenine may be mediated through the formation of interferon.

Entities: Chemical Species

Mesh：

Substances：

Year: 1966 PMID： 5933468 PMCID： PMC2180457 DOI： 10.1084/jem.123.4.577

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

12 in total

1. INTERFERON PRODUCTION INDUCED BY STATOLON.

Authors: W J KLEINSCHMIDT; J C CLINE; E B MURPHY
Journal: Proc Natl Acad Sci U S A Date: 1964-09 Impact factor: 11.205

2. INTERFERON RESPONSES OF CHICK EMBRYO FIBROBLASTS TO NUCLEIC ACIDS AND RELATED COMPOUNDS.

Authors: K E JENSEN; A L NEAL; R E OWENS; J WARREN
Journal: Nature Date: 1963-11-02 Impact factor: 49.962

Review 3. IMMUNOLOGIC, CHEMOTHERAPEUTIC AND INTERFERON APPROACHES TO CONTROL OF VIRAL DISEASE.

Authors: M R HILLEMAN
Journal: Am J Med Date: 1965-05 Impact factor: 4.965

4. GENETIC STUDIES OF INFLUENZA VIRUSES. II. PLAQUE FORMATION BY INFLUENZA VIRUSES IN A CLONE OF A VARIANT HUMAN HETEROPLOID CELL LINE.

Authors: A SUGIURA; E D KILBOURNE
Journal: Virology Date: 1965-07 Impact factor: 3.616

5. Biological studies of interferon. I. Suppression of cellular infection with eastern equine encephalomyelitis virus.

Authors: R R WAGNER
Journal: Virology Date: 1961-03 Impact factor: 3.616

6. Virus interference. I. The interferon.

Authors: A ISAACS; J LINDENMANN
Journal: Proc R Soc Lond B Biol Sci Date: 1957-09-12

7. Interferon activity associated with high molecular weight proteins in the circulation of mice injected with endotoxin or bacteria.

Authors: J V Hallum; J S Youngner; W R Stinebring
Journal: Virology Date: 1965-11 Impact factor: 3.616

8. Interferon-Like Virus-Inhibitor Induced in Human Leukocytes by Phytohemagglutinin.

Authors: E F Wheelock
Journal: Science Date: 1965-07-16 Impact factor: 47.728

9. An antiviral substance from Penicillium funiculosum. III. General properties and characteristics of helenine.

Authors: R E SHOPE
Journal: J Exp Med Date: 1953-05 Impact factor: 14.307

10. An antiviral substance from Penicillium funiculosum. IV. Inquiry into the mechanism by which helenine exerts its antiviral effect.

Authors: R E Shope
Journal: J Exp Med Date: 1966-02-01 Impact factor: 14.307

11 in total

1. Various molecular species of interferon induced by viral and nonviral agents.

Authors: T C Merigan
Journal: Bacteriol Rev Date: 1967-06

Review 2. Fungal viruses.

Authors: P A Lemke; C H Nash
Journal: Bacteriol Rev Date: 1974-03

10. An antiviral substance from Penicillium funiculosum. VI. Prevention of the establishment of passive immunity to Semliki Forest virus infection in mice by Helenine.

Authors: R E Shope
Journal: J Exp Med Date: 1966-07-01 Impact factor: 14.307

An antiviral substance from Penicillium funiculosum. V. Induction of interferon by helenine.

1. INTERFERON PRODUCTION INDUCED BY STATOLON.

2. INTERFERON RESPONSES OF CHICK EMBRYO FIBROBLASTS TO NUCLEIC ACIDS AND RELATED COMPOUNDS.

Review 3. IMMUNOLOGIC, CHEMOTHERAPEUTIC AND INTERFERON APPROACHES TO CONTROL OF VIRAL DISEASE.

4. GENETIC STUDIES OF INFLUENZA VIRUSES. II. PLAQUE FORMATION BY INFLUENZA VIRUSES IN A CLONE OF A VARIANT HUMAN HETEROPLOID CELL LINE.

5. Biological studies of interferon. I. Suppression of cellular infection with eastern equine encephalomyelitis virus.

6. Virus interference. I. The interferon.

7. Interferon activity associated with high molecular weight proteins in the circulation of mice injected with endotoxin or bacteria.

8. Interferon-Like Virus-Inhibitor Induced in Human Leukocytes by Phytohemagglutinin.

9. An antiviral substance from Penicillium funiculosum. III. General properties and characteristics of helenine.

10. An antiviral substance from Penicillium funiculosum. IV. Inquiry into the mechanism by which helenine exerts its antiviral effect.

1. Various molecular species of interferon induced by viral and nonviral agents.

Review 2. Fungal viruses.

Review 3. Virus infections and respiratory disease of childhood.

4. Interferon induction.

5. Antiviral agents in practice.

6. Inducers of interferon and host resistance. I. Double-stranded RNA from extracts of Penicillium funiculosum.

7. Inhibition of Sindbis virus plaque formation by extracts of Escherichia coli.

8. Antiviral activity of polyacrylic and polymethacrylic acids. II. Mode of action in vivo.

Review 9. Mycoviruses: a new dimension in microbiology.

10. An antiviral substance from Penicillium funiculosum. VI. Prevention of the establishment of passive immunity to Semliki Forest virus infection in mice by Helenine.