Literature DB >> 593290

Ataxia telangiectasia: the effects of chemical mutagens and x-rays on sister chromatid exchanges in blood lymphocytes.

S M Galloway.   

Abstract

It is now possible to examine in detail exchanges between sister chromatids (SCEs) and to attempt to investigate the relationships of such exchanges to aberration formation and DNA-repair mechanisms. The frequency of SCEs is dramatically increased by chemical mutagens and may reflect the level of DNA damage. Lymphocytes from patients with ataxia telangiectasis (AT) show high levels of spontaneous chromosome damage and are hypersentive to ionising radiations and it was of interest to examine the levels of SCE induced in these cells by various mutagens. The frequencies of SCE after treatment with X=rays or three chemical mutagens were equivalent to those in normal cells. The effects of fluorodeoxyuridine and deoxycytidine on SCE frequencies were also tested.

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Year:  1977        PMID： 593290     DOI： 10.1016/0027-5107(77)90144-0

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  7 in total

1.  The controlling role of ATM in homologous recombinational repair of DNA damage.

Authors:  C Morrison; E Sonoda; N Takao; A Shinohara; K Yamamoto; S Takeda
Journal:  EMBO J       Date:  2000-02-01       Impact factor: 11.598

2.  Cells from an immunodeficient patient (46BR) with a defect in DNA ligation are hypomutable but hypersensitive to the induction of sister chromatid exchanges.

Authors:  L M Henderson; C F Arlett; S A Harcourt; A R Lehmann; B C Broughton
Journal:  Proc Natl Acad Sci U S A       Date:  1985-04       Impact factor: 11.205

3.  Effects of alkylating agents on lymphocytes from controls and from patients with Fanconi's anemia. Studies of sister chromatid exchanges, chromosome aberrations, and kinetics of cell division.

Authors:  B Novotná; P Goetz; N I Surkova
Journal:  Hum Genet       Date:  1979-05-23       Impact factor: 4.132

Review 4.  Sister chromatid exchange (SCE) and structural chromosome aberration in mutagenicity testing.

Authors:  E Gebhart
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

Review 5.  Sister chromatid exchange analysis.

Authors:  S A Latt; R R Schreck
Journal:  Am J Hum Genet       Date:  1980-05       Impact factor: 11.025

6.  Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange.

Authors:  Jason S White; Serah Choi; Christopher J Bakkenist
Journal:  Sci Signal       Date:  2010-06-01       Impact factor: 8.192

7.  Inhibition of ATM kinase activity does not phenocopy ATM protein disruption: implications for the clinical utility of ATM kinase inhibitors.

Authors:  Serah Choi; Armin M Gamper; Jason S White; Christopher J Bakkenist
Journal:  Cell Cycle       Date:  2010-10-27       Impact factor: 4.534
  7 in total

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