Literature DB >> 592335

Bradykinin potentiating and sensitizing activities of new synthetic analogues of snake venom peptides.

E B Sabia, M Tominaga, A C Paiva, T B Paiva.   

Abstract

The structural requirements for prolonged residual ("sensitizing") activity in bradykinin-potentiating peptides (BPP's) were investigated through a study of seven synthetic BPP's including three not previously described: [Lys6]-BPP9a, [Gly6]potentiator B, and [Lys6,Gln8]potentiator B. The quantitation of the sensitizing activities in the isolated guinea pig ileum indicated that the structural requirements for bradykinin potentiation and for sensitization were not the same. The most potent sensitizers were potentiator B and [Lys6]-BPP9a.

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Year:  1977        PMID： 592335     DOI： 10.1021/jm00222a030

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  3 in total

1.  Further evidence for the existence of two receptor sites for bradykinin responsible for the diphasic effect in the rat isolated duodenum.

Authors:  P Boschcov; A C Paiva; T B Paiva; S I Shimuta
Journal:  Br J Pharmacol       Date:  1984-10       Impact factor: 8.739

2.  Reactivity to bradykinin and potassium of the isolated duodenum from rats with genetic and renal hypertension.

Authors:  N Miasiro; T B Paiva; C C Pereira; S I Shimuta
Journal:  Br J Pharmacol       Date:  1985-07       Impact factor: 8.739

3.  Effect of treatment with vitamin D3 on the responses of the duodenum of spontaneously hypertensive rats to bradykinin and to potassium.

Authors:  T Feres; L M Vianna; A C Paiva; T B Paiva
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739
  3 in total

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