| Literature DB >> 592321 |
B Blank, N W DiTullio, L Deviney, J T Roberts, A Magnani, M Billig, H L Saunders.
Abstract
3-Mercapto-4-methylpicolinic acid one of very few compounds derived from 3-mercaptopicolinic acid (3-MPA) to have hypoglycemic activity. In an effort to find compounds with greater potency than 3-MPA, several 4-substituted 3-mercaptopicolinic acids (4-OMe, OC6H5, SMe, SH, Cl, NH2, Et; 1-7) were prepared and tested in 48-h fasted rats. None was hypoglycemic in this test system after oral dosing of 150 mg/kg.Entities:
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Year: 1977 PMID： 592321 DOI： 10.1021/jm00222a007
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446