Literature DB >> 591976

Is malignant hyperpyrexia muscle denervated?

R F Moulds.   

Abstract

To test the hypothesis that human muscular dystrophies may be secondary to denervation, the responses in vitro of muscle in human malignant hyperpyrexia to electrical and pharmacological stimuli have been compared with those of the denervated mouse soleus muscle. The results suggest that the muscle abnormality in malignant hyperpyrexia is different from that produced by denervation. This must cast doubt on the concept that other human muscular dystrophies are secondary to denervation.

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Year:  1977        PMID: 591976      PMCID: PMC492879          DOI: 10.1136/jnnp.40.10.975

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN: 0022-3050            Impact factor:   10.154


  12 in total

1.  A study of the action of caffeine, halothane, potassium chloride and procaine on normal human skeletal muscle.

Authors:  R F Moulds; M A Denborough
Journal:  Clin Exp Pharmacol Physiol       Date:  1974 May-Jun       Impact factor: 2.557

2.  Inheritance of malignant hyperpyrexia.

Authors:  J O King; M A Denborough; P W Zapf
Journal:  Lancet       Date:  1972-02-12       Impact factor: 79.321

3.  Trophic functions of the neuron. II. Denervation and regulation of muscle. Physiological effects of denervation of muscle.

Authors:  S Thesleff
Journal:  Ann N Y Acad Sci       Date:  1974-03-22       Impact factor: 5.691

4.  Trophic functions of the neuron. IV. Clinical disorders of trophic functions muscular dystrophy? Sick motoneurons and muscle disease.

Authors:  A J McComas; R E Sica; A R Upton; F Petito
Journal:  Ann N Y Acad Sci       Date:  1974-03-22       Impact factor: 5.691

5.  Action potential generation in denervated rat skeletal muscle. I. Quantitative aspects.

Authors:  P Redfern; S Thesleff
Journal:  Acta Physiol Scand       Date:  1971-04

6.  Halothane-induced muscle contracture as a cause of hyperpyrexia.

Authors:  F R Ellis; D G Harriman; N P Keaney; K Kyei-Mensah; J H Tyrrell
Journal:  Br J Anaesth       Date:  1971-07       Impact factor: 9.166

7.  Metabolic error of muscle metabolism after recovery from malignant hyperthermia.

Authors:  W Kalow; B A Britt; M E Terreau; C Haist
Journal:  Lancet       Date:  1970-10-31       Impact factor: 79.321

8.  Biochemical basis of malignant hyperpyrexia.

Authors:  R F Moulds; M A Denborough
Journal:  Br Med J       Date:  1974-05-04

9.  A comparison of the effects of sodium thiocyanate and dantrolene sodium on a mammalian isolated skeletal muscle.

Authors:  R F Moulds
Journal:  Br J Pharmacol       Date:  1977-01       Impact factor: 8.739

10.  The mechanism of the action of caffeine on sarcoplasmic reticulum.

Authors:  A Weber
Journal:  J Gen Physiol       Date:  1968-11       Impact factor: 4.086

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