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Literature DB >> 5919363

A distinctive fraction of alkaline phosphatase in health and disease.

Abstract

An electrophoretic fraction of plasma alkaline phosphatase, which migrates more slowly than the main fraction, was present in one fifth of normal subjects, and in some patients with parenchymal liver disease. It was absent in patients with bone disease, uncomplicated biliary obstruction, and hepatic metastases. The electrophoretic and inhibition properties of this slow band were similar to those of intestinal phosphatase, and its significance is discussed. In a patient with hypophosphatasia this fraction was apparently not decreased.

Entities: Disease Species

Mesh：

Substances：
Alkaline Phosphatase

Year: 1966 PMID： 5919363 PMCID： PMC473357 DOI： 10.1136/jcp.19.5.491

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

24 in total

1. GENETIC VARIATIONS OF HUMAN SERUM PHOSPHATASES.

Authors: K E ARFORS; L BECKMAN; L G LUNDIN
Journal: Acta Genet Stat Med Date: 1963

2. Differentiation into three fractions of the serum alkaline phosphatase and the behavior of the fractions in diseases of bone and liver.

Authors: N R KEIDING
Journal: Scand J Clin Lab Invest Date: 1959 Impact factor: 1.713

3. Serum alkaline phosphatase fractions in hepato-biliary and bone diseases.

Authors: L CHIANDUSSI; S F GREENE; S SHERLOCK
Journal: Clin Sci Date: 1962-06 Impact factor: 6.124

4. Iso-enzymes of alkaline phosphatase.

Authors: A W HODSON; A L LATNER; L RAINE
Journal: Clin Chim Acta Date: 1962-03 Impact factor: 3.786

5. Serum alkaline phosphatase activity in diseases of the skeletal and hepatobiliary systems. A consideration of the current status.

Authors: A B GUTMAN
Journal: Am J Med Date: 1959-12 Impact factor: 4.965

6. Chromatography of serum proteins in normal and pathologic sera: the distribution of protein-bound carbohydrate and cholesterol, siderophilin, thyroxin-binding protein, B12-binding protein, alkaline and acid phosphatases, radio-iodinated albumin and myeloma proteins.

Authors: J L FAHEY; P F McCOY; M GOULIAN
Journal: J Clin Invest Date: 1958-02 Impact factor: 14.808

7. Starch gel electrophoresis in a discontinous system of buffers.

Authors: M D POULIK
Journal: Nature Date: 1957-12-28 Impact factor: 49.962

8. Genetic, clinical, biochemical, and pathological features of hypophosphatasia; based on the study of a family.

Authors: A M BARRETT; D V FAIRWEATHER; R A MCCANCE; A B MORRISON
Journal: Q J Med Date: 1956-10

9. Separation and purification of enzymes associated with insoluble particles.

Authors: R K MORTON
Journal: Nature Date: 1950-12-30 Impact factor: 49.962

10. Metabolism and excretion of alkaline phosphatase: relation to liver function and determination of maximal secretory rates of liver.

Authors: H H LeVEEN; L J TALBOT; M RESTUCCIA; J R BARBERIO
Journal: J Lab Clin Med Date: 1950-08

4 in total

1. Intestinal alkaline phosphatase in patients with liver disease.

Authors: M Barakat; M N Grubb; R K Goyal; T Hersh
Journal: Am J Dig Dis Date: 1971-12

2. Serum alkaline phosphatase in hypophosphatasia.

Authors: J B Warshaw; J W Littlefield; W H Fishman; N R Inglis; L L Stolbach
Journal: J Clin Invest Date: 1971-10 Impact factor: 14.808

3. Plasma intestinal alkaline phosphatase and intermediate molecular mass gamma glutamyltransferase activities in the differential diagnosis of jaundice.

Authors: D Collins; M F Goold; S B Rosalki; P D Mayne; A Y Foo
Journal: J Clin Pathol Date: 1987-10 Impact factor: 3.411

4. Intestinal origin alkaline phosphatase activity in plasma for differential diagnosis of jaundice.

Authors: T Kuwana; S B Rosalki
Journal: J Clin Pathol Date: 1991-10 Impact factor: 3.411

4 in total