| Literature DB >> 5917775 |
Abstract
The abnormal base, 7-methylguanine, has been introduced into copolymers of uridylic and guanylic acids by methylation under controlled conditions. The resulting methylated copolymers have a markedly decreased template activity for polypeptide synthesis in vitro due to steric effects of the 7-methyl groups. Contrary to expectation, these polymers do not permit incorporation of amino acids whose codons contain the bases uracil and adenine.Entities:
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Year: 1966 PMID： 5917775 DOI： 10.1126/science.153.3742.1403
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728