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Literature DB >> 5914758

Muscle postjunctional membrane: changes in chemosensitivity produced by calcium.

Abstract

Increases in the extracellular concentration of calcium ions above 1.8 millimoles per liter caused a reversible decrease in the sensitivity of tmuscle postiunctional membrane to carbamylcholine. A quantitative study of the inhibitory effect of calcium ions on membrane depolarization produced by carbamylcholine indicates that calcium ions compete with carbamylcholine for some common binding sites on the postjunctional membrane. Calcium ions (20 millimoles per liter) caused a neuromuscular block wherein prolonged end plate potentials were produced after nerve stimulation. Calcium ions applied ionophoretically to the postjunctional membrane decreased the amplitude and prolonged the time course of the transient depolarization produced by ionophoretically applied carbamylcholine.

Entities: Chemical Disease

Mesh：

Substances：
Carbachol
Calcium

Year: 1966 PMID： 5914758 DOI： 10.1126/science.154.3746.266

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

12 in total

1. Histochemical and cytochemical studies of alkaline phosphatase activity in the synapses of rat brain.

Authors: K Sugimura; A Mizutani
Journal: Histochemistry Date: 1979-06-18

2. Modification of the nicotine-induced depolarization in striated muscle by altered (H + ) 0, (Ca ++ ) 0 and (Cl - ) 0 .

Authors: E G Henderson; L Reynolds
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1973 Impact factor: 3.000

3. Characteristics of fast excitatory postsynaptic current in bullfrog sympathetic ganglion cells. Effects of membrane potential, temperature and Ca ions.

Authors: K Kuba; S Nishi
Journal: Pflugers Arch Date: 1979-01-31 Impact factor: 3.657

Muscle postjunctional membrane: changes in chemosensitivity produced by calcium.

1. Histochemical and cytochemical studies of alkaline phosphatase activity in the synapses of rat brain.

2. Modification of the nicotine-induced depolarization in striated muscle by altered (H + ) 0, (Ca ++ ) 0 and (Cl - ) 0 .

3. Characteristics of fast excitatory postsynaptic current in bullfrog sympathetic ganglion cells. Effects of membrane potential, temperature and Ca ions.

4. Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release.

5. Co-operative action a calcium ions in transmitter release at the neuromuscular junction.

6. The effect of external calcium and magnesium ions on the response of denervated muscle to acetylcholine.

7. Calcium uptake and bioelectrical activity of denervated and myotonic muscle.

8. Manganese ions and synaptic transmission in the superior cervical ganglion of the cat.

9. Activation of transmitter release by strontium and calcium ions at the neuromuscular junction.

10. Two-component desensitization at the neuromuscular junction of the frog.