Literature DB >> 5911531

Dealkylation studies on inhibited acetylcholinesterase.

D B Coult, D J Marsh, G Read.   

Abstract

1. A rapid method for measuring the rate of dealkylation of organophosporus-inhibited enzymes is described. 2. The dealkylation rates have been measured for acetylcholinesterase inhibited by isopropyl, sec.-butyl, 1,2-dimethylpropyl, 1,2,2-trimethylpropyl and cyclohexyl methylphosphonofluoridate, and by di-isopropyl phosphorofluoridate; they are first-order under the conditions used.

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Year:  1966        PMID： 5911531      PMCID： PMC1264930          DOI： 10.1042/bj0980869

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  6 in total

1.  ANTIDOTAL ACTION OF PYRIDINIUM OXIMES IN ANTICHOLINESTERASE POISONING; COMPARATIVE EFFECTS OF SOMAN, SARIN, AND NEOSTIGMINE ON NEUROMUSCULAR FUNCTION.

Authors:  T A LOOMIS; B SALAFSKY
Journal:  Toxicol Appl Pharmacol       Date:  1963-11       Impact factor: 4.219

2.  Chemical nature of the DFP-binding site of pseudocholinesterase.

Authors:  H S JANSZ; D BRONS; M G WARRINGA
Journal:  Biochim Biophys Acta       Date:  1959-08

3.  The reactivation by oximes and hydroxamic acids of cholinesterase inhibited by organo-phosphorus compounds.

Authors:  A F CHILDS; D R DAVIES; A L GREEN; J P RUTLAND
Journal:  Br J Pharmacol Chemother       Date:  1955-12

4.  Effect of nicotinhydroxamic acid methiodide on human plasma cholinesterase inhibited by organophosphates containing a dialkylphosphato group.

Authors:  F HOBBIGER
Journal:  Br J Pharmacol Chemother       Date:  1955-09

5.  The mechanism of inhibition of cholinesterases by organophosphorus compounds.

Authors:  W N ALDRIDGE; A N DAVISON
Journal:  Biochem J       Date:  1953-12       Impact factor: 3.857

6.  Protection against the lethal effects of organophosphates by pyridine-2-aldoxime methiodide.

Authors:  F HOBBIGER
Journal:  Br J Pharmacol Chemother       Date:  1957-12
  6 in total
  9 in total

1.  The nature of the reaction of organophosphorus compounds and carbamates with esterases.

Authors:  W N Aldridge
Journal:  Bull World Health Organ       Date:  1971       Impact factor: 9.408

2.  [Pyridinium and imidazolium salts as antidotes for soman and paraoxon poisoning in mice].

Authors:  H Oldiges; K Schoene
Journal:  Arch Toxikol       Date:  1970

3.  Obidoxime reactivation of organophosphate-inhibited cholinesterase activity in pigs.

Authors:  N Gyrd-Hansen; I Kraul
Journal:  Acta Vet Scand       Date:  1984       Impact factor: 1.695

4.  Survivors of soman poisoning: recovery of the soman LD50 to control value in the presence of extensive acetylcholinesterase inhibition.

Authors:  J G Clement
Journal:  Arch Toxicol       Date:  1989       Impact factor: 5.153

5.  Reduced clearance of proteins labeled with diisopropylfluorophosphate in portacaval-shunted rats.

Authors:  Gerald A Dienel; Nancy F Cruz
Journal:  Metab Brain Dis       Date:  2013-10-25       Impact factor: 3.584

6.  Effects of repeated injection of sublethal doses of soman on behavior and on brain acetylcholine and choline concentrations in the rat.

Authors:  T M Shih; D E Lenz; D M Maxwell
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

7.  Effect of pH on inhibition and spontaneous reactivation of acetylcholinesterase treated with esters of phosphorus acids and of carbamic acids.

Authors:  E Reiner; W N Aldridge
Journal:  Biochem J       Date:  1967-10       Impact factor: 3.857

8.  The effect of trichlorfon and other organophosphates on prenatal brain development in the guinea pig.

Authors:  A Mehl; T M Schanke; B A Johnsen; F Fonnum
Journal:  Neurochem Res       Date:  1994-05       Impact factor: 3.996

9.  Acetylcholinesterase in the fast extraocular muscle of the mouse by light and electron microscope autoradiography.

Authors:  M M Salpeter; A W Rogers; H Kasprzak; F A McHenry
Journal:  J Cell Biol       Date:  1978-07       Impact factor: 10.539
  9 in total

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