| Literature DB >> 5907913 |
E Valdivia, J Sonnad, J D'Amato.
Abstract
Fat vacuoles develop in the granular pneumocytes of guinea pigs exposed to severe hypoxia in low-pressure chambers. The ostiniophilic lamellar bodies are apparently reduced in size and decreased in number. The fatty change of the granular pneumocyte may represent a metabolic alteration and interfere with the production of surfactant. This hypoxic lesion of the pneumocyte may be a significant factor in high-altitude pulmonary insufficiency.Entities:
Mesh：
Substances：
Year: 1966 PMID： 5907913 DOI： 10.1126/science.151.3707.213
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728