Literature DB >> 590458

The opposed influences of beta-adrenergic stimulation and adenosine on the frequency-force relationship of isolated left atria of guinea-pigs.

D Hilgemann, R Englert, H J Mensing.   

Abstract

The normal frequency-force relationship of left guinea-pig atria can be largely suspended when strong beta-adrenergic stimulation by orciprenaline is antagonized by the negative inotropic effect of adenosine, so that contraction amplitude is nearly equal at an intermediate level over a wide range of stimulation rates. Curves obtained with new method for recording continuous frequency-force loops are presented.

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Year:  1977        PMID： 590458     DOI： 10.1007/bf01934040

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  13 in total

Review 1.  THE INFLUENCE OF THE INTERVAL BETWEEN BEATS ON MYOCARDIAL CONTRACTILITY.

Authors:  J KOCH-WESER; J R BLINKS
Journal:  Pharmacol Rev       Date:  1963-09       Impact factor: 25.468

2.  Analysis of the effects of changes in rate and rhythm upon myocardial contractility.

Authors:  J R BLINKS; J KOCH-WESER
Journal:  J Pharmacol Exp Ther       Date:  1961-12       Impact factor: 4.030

3.  Slow Ca2+ and Na+ responses induced by isoproterenol and methylxanthines in isolated perfused guinea pig hearts exposed to elevated K+.

Authors:  J A Schneider; N Sperelakis
Journal:  J Mol Cell Cardiol       Date:  1975-04       Impact factor: 5.000

4.  Implications of cyclic nucleotide oscillations during the myocardial contraction cycle.

Authors:  G Brooker
Journal:  Adv Cyclic Nucleotide Res       Date:  1975

5.  The continuous and simultaneous measurement of O2-consumption, rate of decarboxylation of 14C-substrates and the performance of spontaneously-beating isolated heart atria of guinea pigs.

Authors:  M Siess; H J Keller; E Schare; J Geissler; G Müller
Journal:  J Mol Cell Cardiol       Date:  1970-09       Impact factor: 5.000

6.  Potency and selectivity in vitro of compounds related to isoprenaline and orciprenaline on beta-adrenoceptors in the guinea-pig.

Authors:  S R O'Donnell; J C Wanstall
Journal:  Br J Pharmacol       Date:  1974-11       Impact factor: 8.739

7.  Convenient apparatus for recording contractions of isolated heart muscle.

Authors:  J R Blinks
Journal:  J Appl Physiol       Date:  1965-07       Impact factor: 3.531

8.  The effect of epinephrine on adenosine 3', 5'-phosphate levels in the isolated perfused rat heart.

Authors:  G A Robison; R W Butcher; I Oye; H E Morgan; E W Sutherland
Journal:  Mol Pharmacol       Date:  1965-09       Impact factor: 4.436

9.  Effect of papaverine on the frequency-force relationship in guinea-pig left atria.

Authors:  D Reinhardt; W Roggenbach; U Schmidt; H J Schümann
Journal:  Eur J Pharmacol       Date:  1977-01-21       Impact factor: 4.432

10.  Inotropic effect of cyclic AMP in calf ventricular muscle studied by a cut end method.

Authors:  R W Tsien; R Weingart
Journal:  J Physiol       Date:  1976-08       Impact factor: 5.182
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