| Literature DB >> 59014 |
D Slone, V Siskind, O P Heinonen, R R Monson, D W Kaufman, S Shapiro.
Abstract
In a cohort of 50 282 gravidas and their offspring in the U.S.A., malformation rates were similar in the children of 35 418 women not exposed to aspirin, 9736 with intermediate exposure, and 5128 women heavily exposed during the first four lunar months of pregnancy. After controlling a wide range of potential confounding factors using multi-variate analysis, the observed and expected numbers for a variety of malformation categories were similar in all three comparison groups. The data suggest that aspirin is not teratogenic.Entities:
Keywords: Americas; Analgesia; Cardiovascular Effects; Central Nervous System Effects; Cohort Analysis; Congenital Abnormalities; Data Analysis; Developed Countries; Diseases; Drugs; Gastrointestinal Effects; Incidence; Measurement; Multivariate Analysis; Neonatal Diseases And Abnormalities; North America; Northern America; Prospective Studies; Research Methodology; Statistical Studies; Studies; Treatment; United States; Urogenital Effects
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Year: 1976 PMID： 59014 DOI： 10.1016/s0140-6736(76)93025-7
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321