| Literature DB >> 59012 |
P Maupas, A Goudeau, P Coursaget, J Drucker, P Bagros.
Abstract
An inactivated vaccine against hepatitis B was prepared from blood-donor HBs antigen purified on immunoadsorbents. Its safety and efficacy were tested in chimpanzees. Vaccination was then applied in an attempt to protect patients and staff in a haemodialysis unit. The efficacy of the vaccine in man was assessed by observing humoral and cellular immune reactions and by comparing changes in HBs antigenaemia in vaccinated and non-vaccinated subjects. The results indicate that this vaccine protects against hepatitis B in the circumstances in which it was administered.Entities:
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Year: 1976 PMID: 59012 DOI: 10.1016/s0140-6736(76)93023-3
Source DB: PubMed Journal: Lancet ISSN: 0140-6736 Impact factor: 79.321