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Literature DB >> 5886

Organic anions induce colinic secretion.

L Bustos-Fernández, E González, L L de Paolo, C D Celener, K O de Furuya.

Abstract

Experiments were conducted by instilling test solutions into the cleaned colon of anesthetized rats. Isotonic test solutions at an acid (2.9% or neutral (7.0) pH and containing acetic acid or acetate ions were used. At the lower pH, acetic acid was absorbed well absorbed and the colon absorbed fluid. The secretory effect could not be reproduced by hydrochloric acid solutions at pH 2.9. Fluid secretion induced by acetic acid was associated with discharge of mucus from goblet cells. The interference of colonic absorption by acetic acid might be important in some diarrheal diseases.

Entities: Chemical Species

Mesh：

Substances：
Acetates
Sodium
Potassium

Year: 1976 PMID： 5886 DOI： 10.1007/BF01071846

Source DB: PubMed Journal: Am J Dig Dis ISSN： 0002-9211

10 in total

Organic anions induce colinic secretion.

1. ABSORPTION OF SHORT CHAIN FATTY ACIDS IN MAN.

2. IN VIVO DIALYSIS OF FAECES AS A METHOD OF STOOL ANALYSIS. I. TECHNIQUE AND RESULTS IN NORMAL SUBJECTS.

3. Absorption of drugs from the rat colon.

4. Stimulation of colonic secretion of water and electrolytes by hydroxy fatty acids.

5. Inhibition of colonic water and electrolyte absorption by fatty acids in man.

6. Effect of luminal pH on the absorption of water, Na + and Cl-by rat intestine in vivo.

7. Absorption of lactic acid from an isolated intestinal segment in the intact rat.

8. Fecal acidorrhea.

9. Transfer of propionate by rat small intestine in vitro.

10. Colonic secretion of water and electrolytes induced by bile acids: perfusion studies in man.

1. Short-chain fatty acids and the colon.

Review 2. The role of dietary fibre in the human colon.

Review 3. Short chain fatty acids in the human colon.

4. Effect of organic acid absorption on bicarbonate transport in rat colon.

5. Absorption of short-chain fatty acids from the human ileum.

6. Effect of lactate and H+ on structure and function of rat intestine.

7. Action of cisapride on rat colonic secretion.

8. Organic anions and the diarrhea of inflammatory bowel disease.

9. Colonic lactate metabolism and D-lactic acidosis.

10. Effect of short-chaim fatty acid on sodium absorption in isolated human colon perfused through the vascular bed.