Literature DB >> 588293

K5 values of some homologous series of barbiturates and the relationship with the lipophilicity and metabolic clearance.

T D Yih, J M van Rossum.   

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Year:  1977        PMID： 588293     DOI： 10.1016/0006-2952(77)90261-1

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


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  7 in total

1.  Prediction of in vivo tissue distribution from in vitro data. 3. Correlation between in vitro and in vivo tissue distribution of a homologous series of nine 5-n-alkyl-5-ethyl barbituric acids.

Authors:  Peter Ballard; David E Leahy; Malcolm Rowland
Journal:  Pharm Res       Date:  2003-06       Impact factor: 4.200

2.  Relationship of octanol/water partition coefficient and molecular weight to cellular permeability and partitioning in s49 lymphoma cells.

Authors:  V A Levin; D Dolginow; H D Landahl; C Yorke; J Csejtey
Journal:  Pharm Res       Date:  1984-11       Impact factor: 4.200

3.  Interaction of 7-n-alkoxycoumarins with cytochrome P-450(2) and their partitioning into liposomal membranes. Assessment of methods for determination of membrane partition coefficients.

Authors:  M Vermeir; N Boens; K P Heirwegh
Journal:  Biochem J       Date:  1992-06-01       Impact factor: 3.857

4.  Dependence of hydrogen peroxide formation in rat liver microsomes on the molecular structure of cytochrome P-450 substrates: a study with barbiturates and beta-adrenoceptor antagonists.

Authors:  A Bast; P A Goossens; E M Savenije-Chapel
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1989 Apr-Jun       Impact factor: 2.441

5.  Liposomes as carriers of poorly water-soluble substrates: linear modelling of membrane systems with catalytic or binding sites of different facedness. Significance of experimental membrane partition coefficients and of kinetic and equilibrium parameters.

Authors:  K P Heirwegh; J A Meuwissen; M Vermeir; H De Smedt
Journal:  Biochem J       Date:  1988-08-15       Impact factor: 3.857

6.  Prediction of hepatic first-pass metabolism and plasma levels following intravenous and oral administration of barbiturates in the rabbit based on quantitative structure-pharmacokinetic relationships.

Authors:  N Watari; Y Sugiyama; N Kaneniwa; M Hiura
Journal:  J Pharmacokinet Biopharm       Date:  1988-06

7.  Relative potencies for barbiturate binding to the Torpedo acetylcholine receptor.

Authors:  B A Dodson; R R Urh; K W Miller
Journal:  Br J Pharmacol       Date:  1990-11       Impact factor: 8.739
  7 in total

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