Literature DB >> 5862425

A fluorimetric study of the hydroxylation of biphenyl in vitro by liver preparations of various species.

P J Creaven, D V Parke, R T Williams.   

Abstract

1. A study has been made of the enzymic hydroxylation of biphenyl by liver microsomal preparations from 11 species of animals, by using a fluorescence method for the micro-estimation of the hydroxylation products, 2- and 4-hydroxybiphenyl. 2. Livers from all species examined produced 4-hydroxybiphenyl, but only those from mice, hamsters, cats, coypus and frogs produced 2-hydroxybiphenyl as well. 3. Adult rat and rabbit livers produced only the 4-isomer, but livers from the young of these species also produced the 2-isomer. 4. The properties and requirements of the 4-hydroxylating enzyme of rabbit liver were studied. 5. The results are discussed and it is suggested that the 2- and 4-hydroxylating enzymes are different.

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Year:  1965        PMID： 5862425      PMCID： PMC1207231          DOI： 10.1042/bj0960879

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  3 in total

1.  Enzymatic hydroxylation of aromatic compounds.

Authors:  C MITOMA; H S POSNER; H C REITZ; S UDENFRIEND
Journal:  Arch Biochem Biophys       Date:  1956-04       Impact factor: 4.013

2.  A spectrofluorimetric study of the 7-hydroxylation of coumarin by liver microsomes.

Authors:  P J Creaven; D V Parke; R T Williams
Journal:  Biochem J       Date:  1965-08       Impact factor: 3.857

3.  The fluorescence of some biphenyl derivatives.

Authors:  J W Bridges; P J Creaven; R T Williams
Journal:  Biochem J       Date:  1965-09       Impact factor: 3.857
  3 in total
  32 in total

1.  Diphasic action of the aliphatic amide, HOE 17879, on hepatic microsomal drug metabolizing enzymes in the mouse.

Authors:  F E Beyhl; E Lindner
Journal:  Experientia       Date:  1976-03-15

2.  The effect of some glucocorticoids on hepatic microsomal hydroxylation in the rat and hamster.

Authors:  J M Tredger; F J McPherson; J Chakraborty; J W Bridges; D V Parke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976       Impact factor: 3.000

3.  Effects of ethoxyquin on hepatic microsomal enzymes.

Authors:  D V Parke; A Rahm; R Walker
Journal:  Biochem J       Date:  1972-11       Impact factor: 3.857

4.  Additive and synergistic inhibition of mammalian microsomal enzyme functions by piperonyl butoxide, safrole and other methylenedioxyphenyl derivatives.

Authors:  M A Friedman; E Arnold; Y Bishop; S S Epstein
Journal:  Experientia       Date:  1971-09-15

5.  The effects of benzopyrene and safrole on biphenyl 2-hydroxylase and other drug-metabolizing enzymes.

Authors:  F J McPherson; J W Bridges; D V Parke
Journal:  Biochem J       Date:  1976-03-15       Impact factor: 3.857

6.  Isolation and identification of a polar metabolite of tetrachlorobiphenyl from bile of rainbow trout exposed to 14C-tetrachlorobiphenyl.

Authors:  M J Melancon; J J Lech
Journal:  Bull Environ Contam Toxicol       Date:  1976-02       Impact factor: 2.151

7.  Chronic oral exposure of rainbow trout (Salmo gairdneri) to a polychlorinated biphenyl (Aroclor 1254): pathological effects.

Authors:  H Nestel; J Budd
Journal:  Can J Comp Med       Date:  1975-04

8.  Studies on the lipid composition of the rat liver endoplasmic reticulum after induction with phenobarbitone and 20-methylcholanthrene.

Authors:  S C Davison; E D Wills
Journal:  Biochem J       Date:  1974-06       Impact factor: 3.857

9.  The effects of carbon disulphide on rat liver microsomal mixed-function oxidases, in vivo and in vitro.

Authors:  M J Obrebska; P Kentish; D V Parke
Journal:  Biochem J       Date:  1980-04-15       Impact factor: 3.857

10.  Structure-Function Studies of Naphthalene, Phenanthrene, Biphenyl, and Their Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6.

Authors:  Tsutomu Shimada; Shigeo Takenaka; Kensaku Kakimoto; Norie Murayama; Young-Ran Lim; Donghak Kim; Maryam K Foroozesh; Hiroshi Yamazaki; F Peter Guengerich; Masayuki Komori
Journal:  Chem Res Toxicol       Date:  2016-05-12       Impact factor: 3.739
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