Literature DB >> 5859731

Beta-solamarine: tumor inhibitor isolated from Solanum dulcamara.

S M Kupchan, S J Barboutis, J R Knox, C A Cam.   

Abstract

An alcoholic extract of Solanum dulcamara L., a plant widely used in folk medicine for treating cancers and warts, shows tumor-inhibitory activity against Sarcoma 180 in mice. Systematic fractionation of the extract has led to isolation and characterization of beta-solamarine as an active principle.

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Year:  1965        PMID： 5859731     DOI： 10.1126/science.150.3705.1827

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  6 in total

1.  Antibiotic action of Solanum incanum Linnaeus.

Authors:  V Beaman-Mbaya; S I Muhammed
Journal:  Antimicrob Agents Chemother       Date:  1976-06       Impact factor: 5.191

2.  Efficacy and mechanisms of alpha-solasonine-and alpha-solamargine-induced cytolysis on two strains of Trypanosoma cruzi.

Authors:  Christopher A Hall; Traci Hobby; Martin Cipollini
Journal:  J Chem Ecol       Date:  2006-11       Impact factor: 2.626

3.  High-performance thin layer chromatography based assay and stress study of a rare steroidal alkaloid solanopubamine in six species of Solanum grown in Saudi Arabia.

Authors:  Nasir A Siddiqui; Mohammad K Parvez; Adnan J Al-Rehaily; Mohammed S Al Dosari; Perwez Alam; Faiyaz Shakeel; Hattan A Al Harbi
Journal:  Saudi Pharm J       Date:  2016-05-26       Impact factor: 4.330

4.  Solamargine induces hepatocellular carcinoma cell apoptosis and autophagy via inhibiting LIF/miR-192-5p/CYR61/Akt signaling pathways and eliciting immunostimulatory tumor microenvironment.

Authors:  Shuangshuang Yin; Wenke Jin; Yuling Qiu; Leilei Fu; Tao Wang; Haiyang Yu
Journal:  J Hematol Oncol       Date:  2022-03-21       Impact factor: 17.388

5.  Solanum Incanum Extract Downregulates Aldehyde Dehydrogenase 1-Mediated Stemness and Inhibits Tumor Formation in Ovarian Cancer Cells.

Authors:  Yi-Hui Wu; Wen-Tai Chiu; Ming-Jer Young; Tzu-Hao Chang; Yu-Fang Huang; Cheng-Yang Chou
Journal:  J Cancer       Date:  2015-08-22       Impact factor: 4.207

6.  Solanum incanum extract (SR-T100) induces melanoma cell apoptosis and inhibits established lung metastasis.

Authors:  Sebastian Yu; Hamm-Ming Sheu; Chih-Hung Lee
Journal:  Oncotarget       Date:  2017-10-04
  6 in total

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