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Literature DB >> 583234

[Chromatographic separation of racemic thalidomide and teratogenic activity of its enantiomers (author's transl)].

G Blaschke, H P Kraft, K Fickentscher, F Köhler.

Abstract

Racemic thalidomide is chromatographically separated on optically active polyamide giving both enantiomers. After i.p. administration only the S-(-)-enantiomer is teratogenic on SWS mice and Natal rats.

Entities: Chemical Species

Mesh：

Substances：
Teratogens
Thalidomide

Year: 1979 PMID： 583234

Source DB: PubMed Journal: Arzneimittelforschung ISSN： 0004-4172

Keyword Cloud
Cited

28 in total

1. Enantioselective disposition of lansoprazole in relation to CYP2C19 genotypes in the presence of fluvoxamine.

Authors: Masatomo Miura; Hitoshi Tada; Norio Yasui-Furukori; Tsukasa Uno; Kazunobu Sugawara; Tomonori Tateishi; Toshio Suzuki
Journal: Br J Clin Pharmacol Date: 2005-07 Impact factor: 4.335

Review 2. Enantiomeric resolution of drug compounds by liquid chromatography.

Authors: H T Karnes; M A Sarkar
Journal: Pharm Res Date: 1987-08 Impact factor: 4.200

Review 3. Drug chirality and its clinical significance.

Authors: A J Hutt; S C Tan
Journal: Drugs Date: 1996 Impact factor: 9.546

4. Embryotoxic effects of thalidomide derivatives on the non-human primate Callithrix jacchus; 3. Teratogenic potency of the EM 12 enantiomers.

Authors: W Heger; S Klug; H J Schmahl; H Nau; H J Merker; D Neubert
Journal: Arch Toxicol Date: 1988 Impact factor: 5.153

9. The enantiomers of the teratogenic thalidomide analogue EM 12: 1. Chiral inversion and plasma pharmacokinetics in the marmoset monkey.

Authors: H J Schmahl; H Nau; D Neubert
Journal: Arch Toxicol Date: 1988 Impact factor: 5.153

10. Synthetic Studies of 3-(3-Fluorooxindol-3-yl)-l-alanine.

Authors: Tomoya Fujiwara; Bin Yin; Meixiang Jin; Kenneth L Kirk; Yoshio Takeuchi
Journal: J Fluor Chem Date: 2008 Impact factor: 2.050

[Chromatographic separation of racemic thalidomide and teratogenic activity of its enantiomers (author's transl)].

1. Enantioselective disposition of lansoprazole in relation to CYP2C19 genotypes in the presence of fluvoxamine.

Review 2. Enantiomeric resolution of drug compounds by liquid chromatography.

Review 3. Drug chirality and its clinical significance.

4. Embryotoxic effects of thalidomide derivatives on the non-human primate Callithrix jacchus; 3. Teratogenic potency of the EM 12 enantiomers.

Review 5. Current status of thalidomide and CC-5013 in the treatment of metastatic prostate cancer.

6. Differential effects of the enantiomers of tamsulosin and tolterodine on P-glycoprotein and cytochrome P450 3A4.

Review 7. Thalidomide and its derivatives: emerging from the wilderness.

8. Pharmacokinetics of (+)-rolipram and (-)-rolipram in healthy volunteers.

9. The enantiomers of the teratogenic thalidomide analogue EM 12: 1. Chiral inversion and plasma pharmacokinetics in the marmoset monkey.

10. Synthetic Studies of 3-(3-Fluorooxindol-3-yl)-l-alanine.