| Literature DB >> 583094 |
F Horvath, P Teague, E F Gaffney, D R Mars, T J Fuller.
Abstract
A 60 year old hyperthyroid black woman with long-standing Graves' disease treated with methimazole presented with anasarca and congestive heart failure. She was found to have the nephrotic syndrome with a urinary protein excretion of 32 g/day. Light and electron microscopy revealed a stage II membranous glomerulopathy. Direct and indirect immunofluorescence demonstrated immunoglobulin G (IgG), immunoglobulin M (IgM), third component of complement and thyroglobulin in a granular diffuse pattern consistent with an immune complex glomerulonephritis. Total thyroidectomy led to a decrease in proteinuria with little change in glomerular filtration rate during an 11 month follow-up period. We believe this to be the first report of immune complex glomerulonephritis associated with thyroid antigen in Graves' disease.Entities:
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Year: 1979 PMID： 583094 DOI： 10.1016/0002-9343(79)90752-6
Source DB: PubMed Journal: Am J Med ISSN： 0002-9343 Impact factor: 4.965