Literature DB >> 582905

[Reactivation of phosphorylated acetylcholinesterase. Isomeric bisquaternary salts of pyridine aldoximes].

I Hagedorn, I Stark, K Schoene, H Schenkel.   

Abstract

Mono-quaternary salts Z have been prepared from pyridine-aldoximes and 1,3-dihalogen compounds. These were used to synthesize asymmetrical bis-quaternary pyridine-oximes with three-membered bridge. The effect of reactivation of phosphorylated AChE by these substances is less than that of obidoxim (Toxogonin).

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Year:  1978        PMID： 582905

Source DB:  PubMed          Journal:  Arzneimittelforschung        ISSN： 0004-4172


  4 in total

1.  Bisquaternary pyridinium oximes: Comparison of in vitro reactivation potency of compounds bearing aliphatic linkers and heteroaromatic linkers for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase.

Authors:  Sandip B Bharate; Lilu Guo; Tony E Reeves; Douglas M Cerasoli; Charles M Thompson
Journal:  Bioorg Med Chem       Date:  2009-11-27       Impact factor: 3.641

2.  Reactivators of organophosphate-inhibited cholinesterase. Phenylhydroxymethyl and cyclohexylhydroxymethyl substituted bis-pyridinium monooximes.

Authors:  V Deljac; M Maksimović; L Radović; D Rakin; V Markov; I Bregovec; Z Binenfeld
Journal:  Arch Toxicol       Date:  1982-03       Impact factor: 5.153

3.  HLö 7 dimethanesulfonate, a potent bispyridinium-dioxime against anticholinesterases.

Authors:  P Eyer; I Hagedorn; R Klimmek; P Lippstreu; M Löffler; H Oldiges; U Spöhrer; I Steidl; L Szinicz; F Worek
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153

4.  Reactivators of organophosphate-inhibited cholinesterase. 4-cycloalkylcarbonyl substituted bis-pyridinium monooximes.

Authors:  M Maksimović; I Bregovec; V Deljac; Z Binenfeld
Journal:  Arch Toxicol       Date:  1984-09       Impact factor: 5.153
  4 in total

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